Results 111 to 120 of about 27,631,015 (306)

Greater Endothelial Apoptosis and Oxidative Stress in Patients with Peripheral Artery Disease

International Journal of Vascular Medicine, 2014
We compared apoptosis, cellular oxidative stress, and inflammation of cultured endothelial cells treated with sera from 156 subjects with peripheral artery disease (PAD) and 16 healthy control subjects.
Andrew W. Gardner, Donald E. Parker, Polly S. Montgomery, Danuta Sosnowska, Ana I. Casanegra, Zoltan Ungvari, Anna Csiszar, William E. Sonntag   +7 more
doaj   +1 more source

Sex Differences in Circulating Progenitor Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundLower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes.
Matthew L. Topel, Salim S. Hayek, Yi‐An Ko, Pratik B. Sandesara, Ayman Samman Tahhan, Iraj Hesaroieh, Ernestine Mahar, Greg S. Martin, Edmund K. Waller, Arshed A. Quyyumi   +9 more
doaj   +1 more source

Angiogenesis-dependent and independent phases of intimal hyperplasia. [PDF]

, 2004
BACKGROUND: Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive vascular disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis is implicated in the
De Muinck, E, Ferrara, N, Simons, M, Khurana, R, Zhuang, Z, Martin, JF, Murakami, M, Zachary, I, Bhardwaj, S, Yla-Herttuala, S   +9 more
core  

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Vascular endothelial growth factor-C reduce the cytotoxicity of cispaltin on human kidney tubular epithelial cells

Linchuang shenzangbing zazhi, 2015
Objective To identify the mRNA expression of VEGF-C on HK-2 cells induced by differrent concentrations of cisplatin and the impact of VEGF-C on the cisplatin-induced cytotoxicity of HK-2cells,and to explore the possible mechanisms.Methods HK-2 cells ...
CHANG Xiao-yan, ZHANG Ying, YANG Qian, HUANG Shuai, XU Gang   +4 more
doaj  

siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells

Tumor Biology, 2017
Human pituitary adenoma is one of the most common intracranial tumors with an incidence as high as 16.7%. Recent evidence has hinted a relationship between growth factors of pituitary or hypothalamic origin and proliferation of human pituitary adenoma ...
Kai Zhou, Yan-Dong Fan, Serick Duysenbi, Peng-Fei Wu, Zhao-Hai Feng, Zheng Qian, Ting-Rong Zhang   +6 more
doaj   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Association of vascular endothelial growth factor C-634 G polymorphism in Taiwanese children with Kawasaki disease [PDF]

, 2010
[[abstract]]High expression of circulating vascular endothelial growth factor (VEGF) has been reported in patients with Kawasaki disease (KD). In the pathophysiology of KD, VEGF is considered to be involved, especially in the development of coronary ...
Hsueh, KC (Hsueh, K. -C.); Lin, YJ (Lin, Y. -J.); Chang, JS (Chang, J. -S.); Wan, L (Wan, L.); Tsai, YH (Tsai, Y. -H.); Tsai, CH (Tsai, C. -H.); Chen, CP (Chen, C. -P.); Tsai, FJ (Tsai, F. -J.)
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source