Results 21 to 30 of about 618,225 (305)

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis [PDF]

The EMBO Journal, 2001
Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary tumours correlates with dissemination of tumour cells to regional lymph nodes.
Mandriota, Stefano Jacopo, Jussila, Lotta, Jeltsch, Michael, Compagni, Amelia, Baetens Baumann, Danielle, Prevo, Remko, Banerji, Suneale, Huarte, Joachim, Montesano, Roberto, Jackson, David G., Orci, Lelio, Alitalo, Kari, Christofori, Gerhard, Pepper, Michael Sean   +13 more
openaire   +3 more sources

Expression of vascular endothelial growth factor C in human pterygium [PDF]

Histochemistry and Cell Biology, 2012
Vascular endothelial growth factor C (VEGF-C) and its receptor VEGFR-3 mediate lymphangiogenesis. In this study, we analyzed the expression of VEGF-C and VEGFR-3 as well as lymphatic vessels in the pterygium and normal conjunctiva of humans. Fifteen primary nasal pterygia and three normal bulbar conjunctivas, surgically removed, were examined in this ...
Fukuhara, Junichi, Kase, Satoru, Ohashi, Tsutomu, Ando, Ryo, Dong, Zhenyu, Noda, Kousuke, Ohguchi, Takeshi, Kanda, Atsuhiro, Ishida, Susumu   +8 more
openaire   +3 more sources

Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression

Technology in Cancer Research & Treatment, 2020
Background: Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 ...
Zhen Xie MD, Tianyue Li MD, Bingtao Huang MM, Shuai Liu MM, Lianguo Zhang MM, Qingguang Zhang MD   +5 more
doaj   +1 more source

Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth factor-C in locally advanced breast cancer patients

Clinics, 2011
BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors.
Luiz Gustavo Oliveira Brito, Viviane Fernandes Schiavon, Jurandyr Moreira de Andrade, Daniel Guimarães Tiezzi, Fernanda Maris Peria, Heitor Ricardo Cosiski Marana   +5 more
doaj   +1 more source

Mononuclear Phagocyte System Depletion Blocks Interstitial Tonicity-Responsive Enhancer Binding Protein/Vascular Endothelial Growth Factor C Expression and Induces Salt-Sensitive Hypertension in Rats [PDF]

, 2010
We showed recently that mononuclear phagocyte system (MPS) cells provide a buffering mechanism for salt-sensitive hypertension by driving interstitial lymphangiogenesis, modulating interstitial Na(+) clearance, and increasing endothelial NO synthase ...
Dahlmann, A., Eckardt, K.U., Goss, J., Kerjaschki, D., Kopp, C., Luft, F.C., Machnik, A., Muller, D.N., Park, J.K., Rooijen, N. van, Titze, J., Wagner, H.   +11 more
core   +2 more sources

Cystatin C Expression is Promoted by VEGFA Blocking, With Inhibitory Effects on Endothelial Cell Angiogenic Functions Including Proliferation, Migration, and Chorioallantoic Membrane Angiogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Vascular development, including vasculogenesis and angiogenesis, is involved in many diseases. Cystatin C (CST3) is a commonly used marker of renal dysfunction, and we have previously reported that its expression level is associated with ...
Zhenkun Li, Shiyuan Wang, Xueyun Huo, Hefen Yu, Jing Lu, Shuangyue Zhang, Xiaohong Li, Qi Cao, Changlong Li, Meng Guo, Jianyi Lv, Xiaoyan Du, Zhenwen Chen   +12 more
doaj   +1 more source

Expression levels of vascular endothelial growth factors A and C in patients with peptic ulcers and gastric cancer [PDF]

, 2014
Purpose: Vascular endothelial growth factor (VEGF) is one of the most important growth factors for metastatic tumors. To clarify the role of VEGF-A and C in patients with peptic ulcer disease (PUD) or gastric cancer (GC), we evaluated the expression ...
Abbasi, A., Ajami, A., Ajami, M., Farazmandfar, T., Hafezi, N., Hosseini, V., Mohammadian, R., Sankian, M., Taghizadeh, S., Tehrani, M.   +9 more
core   +2 more sources

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

Clinicopathological impact of VEGFR2 and VEGF‐C in patients with EGFR‐major mutant NSCLC receiving osimertinib

Thoracic Cancer, 2023
Background Vascular endothelial growth factor (VEGF) has been identified as one of the resistant mechanisms to epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs).
Kyoichi Kaira, Hisao Imai, Atsuto Mouri, Kosuke Hashimoto, Yu Miura, Ayako Shiono, Ou Yamaguchi, Kunihiko Kobayashi, Tomonori Kawasaki, Masanori Yasuda, Hiroshi Kagamu   +10 more
doaj   +1 more source

VEGF: An essential mediator of both angiogenesis and endochondral ossification [PDF]

, 2007
During bone growth, development, and remodeling, angiogenesis as well as osteogenesis are closely associated processes, sharing some essential mediators.
Dai, J, Rabie, ABM
core   +1 more source