Results 31 to 40 of about 618,225 (305)

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway [PDF]

, 2014
Background: Signaling through vascular endothelial growth factor C (VEGF–C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis and the metastasis of several cancers via the lymphatics.
Groopman, Jerome E, Jiang, Shuxian, Kuzontkoski, Paula M, Li, Dean Y, Yu, Jinlong, Zhang, Xuefeng, Zhu, Weiquan   +6 more
core   +2 more sources

Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. [PDF]

PLoS ONE, 2014
There is an ongoing debate as to whether early diabetic nephropathy in Type 2 diabetes mellitus may be attributed to the glomerulus or to the proximal tubule.
Ligia Petrica, Adrian Vlad, Gheorghe Gluhovschi, Florica Gadalean, Victor Dumitrascu, Cristina Gluhovschi, Silvia Velciov, Flaviu Bob, Daliborca Vlad, Roxana Popescu, Oana Milas, Sorin Ursoniu   +11 more
doaj   +1 more source

VEGF-C and podoplanin, as biomarkers of sepsis. An experimental study

Romanian Journal of Laboratory Medicine, 2021
Background: Sepsis is the leading cause of morbidity and mortality in intensive care units. This study explored the possible role of vascular endothelial growth factor-C (VEGF-C) and podoplanin (PDPN) in sepsis.
Almasy Emoke, Szederjesi Janos, Grigorescu Bianca-Liana, Gurzu Simona, Lazar Alexandra, Raduly Gergo, Man Adrian, Oprica Madalina, Saplacan Irina, Copotoiu Sanda-Maria   +9 more
doaj   +1 more source

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]

PLoS ONE, 2012
Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue, Alana L Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y Li, Andreas Bikfalvi, Patrick Auguste   +6 more
doaj   +1 more source

VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy- Terminal NRP1 Fragments That Regulate Angiogenic Signaling [PDF]

, 2018
OBJECTIVE: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism
Evans, I M, Field, L, Jones, T, Mahmoud, M, Mehta, V, Pellet-Many, C, Yamaji, M, Zachary, I   +7 more
core   +3 more sources

Cerebral and systemic endothelial dysfunction in migraine: Current knowledge and perspective [PDF]

Romanian Journal of Neurology, 2021
Migraine still causes a high rate of disability and is reported to increase the risk of cardiovascular and cerebrovascular diseases. Endothelial dysfunction is considered to be one of the underlying mechanisms linking migraine and vascular disorders ...
I Made Oka Adnyana, Valentina Tjandra Dewi   +1 more
doaj   +1 more source

Composite Hydrogels with the Simultaneous Release of VEGF and MCP-1 for Enhancing Angiogenesis for Bone Tissue Engineering Applications [PDF]

, 2018
Rapid new microvascular network induction was critical for bone regeneration, which required the spatiotemporal delivery of growth factors and transplantation of endothelial cells.
Chang, Pengbo, Guo, Peiyin, Huo, Haojie, Ji, Chingching, Nie, Lei, Sun, Meng, Wei, Xiaoyan, Yuan, Hongyu, Zhang, Chunxia, Zhou, Qiuju   +9 more
core   +1 more source

Vascular endothelial growth factor +405G/C polymorphism as a predictor of diabetic retinopathy

Bulletin of the National Research Centre, 2020
Background Diabetic retinopathy is a multistage event, and the most important of it is angiogenesis. The possible association between vascular endothelial growth factor (VEGF) +405G/C gene polymorphism and various diseases, in which angiogenesis might be
Azza K. Amer, Nervana A. Khalaf, Safia H. Aboelmakarem, Mehry S. Elsobky, Mona R. Abdelrasoul, Amira A. Abdelazeem, Shahira R. Noweir, Safa Refaat, Leqaa A. Moemen, Soheir A. Mohammed, Mona A. Abdelhameed, Mohmoud M. Kenawy, Manal H. Abuelela, Marwa A. Fouly, Olfat A. Hassanin, Sherif M. Saadeldin Karawya, Zeinab M. Osman   +16 more
doaj   +1 more source

Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis. [PDF]

PLoS ONE, 2015
In non-small cell lung cancer (NSCLC), nodal metastasis is an adverse prognostic factor. Several mediating factors have been implied in the development of nodal metastases and investigated for predictive and prognostic properties in NSCLC. However, study
Thomas K Kilvaer, Erna-Elise Paulsen, Sigurd M Hald, Tom Wilsgaard, Roy M Bremnes, Lill-Tove Busund, Tom Donnem   +6 more
doaj   +1 more source

Proinflammatory Cytokines Regulate Expression of the Lymphatic Endothelial Mitogen Vascular Endothelial Growth Factor-C [PDF]

Journal of Biological Chemistry, 1998
Vascular endothelial growth factor (VEGF) is a prime regulator of normal and pathological angiogenesis. Three related endothelial cell growth factors, VEGF-B, VEGF-C, and VEGF-D were recently cloned. We have here studied the regulation of VEGF-C, a lymphatic endothelial growth factor, by angiogenic proinflammatory cytokines.
A, Ristimäki, K, Narko, B, Enholm, V, Joukov, K, Alitalo   +4 more
openaire   +2 more sources