Results 61 to 70 of about 27,631,015 (306)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The role of vascular endothelial growth factor C in thyroid cancer metastasis

Mìžnarodnij Endokrinologìčnij Žurnal
Background. The vascular endothelial growth factor (VEGF) system includes several ligands: VEGF-A, VEGF-B, VEGF-C, VEGF-D and their receptors: VEGFR-1, VEGFR-2, and VEGFR-3.
N.Ya. Kobrynska, I.I. Komisarenko, V.M. Pushkarev, N.I. Levchuk, O.I. Kovzun, B.B. Guda, V.V. Pushkarev, M.D. Tronko   +7 more
doaj   +1 more source

Interrelationship between circulating vascular еndothelial growth factor-1 and high-sensitive C-reactive protein in stage III arterial hypertension patients

Zaporožskij Medicinskij Žurnal, 2013
Introduction. Arterial hypertension is one of the most important causes of mortality in the world. Vascular endothelial growth factor-1 (VEGF-1) pathways are the most frequently involved in hypertension development, especially related cardiovascular ...
A. E. Berezin, O. A. Lisovaya
doaj   +1 more source

Hepatocyte growth factor increases vascular endothelial growth factor-A production in human synovial fibroblasts through c-Met receptor pathway. [PDF]

PLoS ONE, 2012
BACKGROUND: Angiogenesis is essential for the progression of osteoarthritis (OA). Hepatocyte growth factor (HGF) is an angiogenic mediator, and it shows elevated levels in regions of OA.
Yu-Min Lin, Yuan-Li Huang, Yi-Chin Fong, Chun-Hao Tsai, Ming-Chih Chou, Chih-Hsin Tang   +5 more
doaj   +1 more source

Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C [PDF]

Journal of Biological Chemistry, 1997
We report here the cloning and characterization of human and mouse genes for vascular endothelial growth factor C (VEGF-C), a newly isolated member of the vascular endothelial growth factor/platelet-derived growth factor (VEGF/PDGF) family. Both VEGF-C genes comprise over 40 kilobase pairs of genomic DNA and consist of seven exons, all containing ...
D, Chilov, E, Kukk, S, Taira, M, Jeltsch, J, Kaukonen, A, Palotie, V, Joukov, K, Alitalo   +7 more
openaire   +2 more sources

Vascular Targeted Agents for the Treatment of Angiosarcoma [PDF]

, 2013
Background: Angiogenesis is the process of new blood vessel formation, and is regulated by angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiosarcomas are rare, aggressive vascular tumours.
P J Woll (16226153), R J Young (13425891), C A Staton (16226156), Malcolm Reed (4465876), Young, Robin, N J Brown (13424178)   +5 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy [PDF]

British Journal of Cancer, 2003
Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival.
Duff, S. E., Li, C., Jeziorska, M., Kumar, S., Saunders, M. P., Sherlock, D., O'Dwyer, S. T., Jayson, G. C.; id_orcid 0000-0002-8515-8944   +7 more
openaire   +2 more sources

Impact of Vitamin D Supplementation on Arterial Vasomotion, Stiffness and Endothelial Biomarkers in Chronic Kidney Disease Patients [PDF]

, 2014
Background: Cardiovascular events are frequent and vascular endothelial function is abnormal in patients with chronic kidney disease (CKD). We demonstrated endothelial dysfunction with vitamin D deficiency in CKD patients; however the impact of ...
Chitalia, N, Hampson, G, Tooth, L, Ismail Tuan, Nihil Chitalia, Debasish Banerjee (539268), Chitalia Nihil, Laura Tooth, Banerjee, D, Ismail, T, Laura Tooth (539265), Geeta Hampson (68251), David Goldsmith (539267), Banerjee Debasish, Boa, F, Juan Carlos Kaski, Kaski Juan Carlos, Tooth Laura, Hampson Geeta, Boa Frances, Nihil Chitalia (539263), Juan Carlos Kaski (248043), Frances Boa (539266), Goldsmith David, Tuan Ismail (539264), Debasish Banerjee, Kaski, JC, David Goldsmith, Geeta Hampson, Tuan Ismail, Goldsmith, D, Frances Boa   +31 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source