Results 71 to 80 of about 618,225 (305)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway. [PDF]

PLoS ONE, 2013
Adiponectin is exclusively expressed in adipose tissues and exhibits protective effects against cardiovascular and metabolic diseases. It enhances AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα) signaling in the liver
Di Hu, Atsunori Fukuhara, Yugo Miyata, Chieko Yokoyama, Michio Otsuki, Shinji Kihara, Iichiro Shimomura   +6 more
doaj   +1 more source

Peritumor Lymphatics Induced by Vascular Endothelial Growth Factor-C Exhibit Abnormal Function [PDF]

Cancer Research, 2004
Abstract Vascular endothelial growth factor (VEGF)-C is known to induce hyperplasia in normal murine lymphatics and in peritumor lymphatics. Here, we examine the function of these hyperplastic peritumor lymphatics. Microlymphangiography of B16F10 melanomas growing in the murine dorsal skinfold chamber showed that the number of functional,
Naohide, Isaka, Timothy P, Padera, Jeroen, Hagendoorn, Dai, Fukumura, Rakesh K, Jain   +4 more
openaire   +2 more sources

In Vivo Fluorescence Imaging of E-Selectin: Quantitative Detection of Endothelial Activation in Arthritis [PDF]

, 2010
Rheumatoid arthritis (RA) is a chronic progressive systemic inflammatory disease, characterized by synovial inflammation and localized destruction of cartilage and bone.
Gompels, Luke, Gompels, Luke
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas [PDF]

Clinical Cancer Research, 2005
Abstract Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype in ovarian carcinomas. Experimental Design: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of the cells ...
Masatsugu, Ueda, Yao-Ching, Hung, Yoshito, Terai, Koji, Kanda, Masanori, Kanemura, Hikari, Futakuchi, Hiroyuki, Yamaguchi, Daisuke, Akise, Masayuki, Yasuda, Minoru, Ueki   +9 more
openaire   +2 more sources

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Adamis, AP, Amano, S, Ambati, J, D'Amore, PA, Gragoudas, ES, Hida, T, Ishida, S, Kaji, Y, Miller, JW, Ng, YS, Oguchi, Y, Ogura, Y, Shima, DT, Usui, T, Yamashiro, K   +14 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Proteolytic Activation of Vascular Endothelial Growth Factor-­C

, 2019
English version of the review "Die proteolytische Aktivierung des Vaskulären Endothelzellwachstumsfaktors-C."
Lackner, Marcel, Schmotz, Constanze, Jeltsch, Michael   +2 more
openaire   +1 more source

Evaluation of Endothelial Cells Differentiated from Amniotic Fluid-Derived Stem Cells [PDF]

, 2012
Amniotic fluid holds great promise as a stem cell source, especially in neonatal applications where autologous cells can be isolated and used. This study examined chemical-mediated differentiation of amniotic fluid-derived stem cells (AFSC) into ...
Anthony Johnson, Jeffrey G. Jacot, Jennifer J. Petsche, Kenneth J. Moise, Omar M. Benavides, Tokalov S.V.   +5 more
core   +1 more source