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RPE and the Vascular Endothelial Growth Factor [PDF]

, 2020
Vascular endothelial growth factor (VEGF) is a major pro-angiogenic cytokine, but also exerts many additional physiological functions in the retina. The retinal pigment epithelium (RPE) is a major source for VEGF in the retina, especially affecting the endothelium of choriocapillaris but also photoreceptors and the RPE itself. VEGF is regulated on many
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Inhibitors of Vascular Endothelial Growth Factor in Cancer

Cardiovascular & Hematological Agents in Medicinal Chemistry, 2008
Angiogenesis is a complex process that is regulated by pro- and antiangiogenic factors. These factors can emanate from diverse sources including cancer cells, stromal cells, blood and extracellular matrix. Their relative contribution is likely to change with tumor type and tumor site.
Mohammad H. Pourgholami, David L. Morris
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Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung

Critical Care Medicine, 2005
Vascular endothelial growth factor (VEGF) regulates vascular proliferation and causes vasodilation. In the pulmonary circulation, the vasorelaxing effect of VEGF has been attributed to nitric oxide, whereas in other vascular beds, prostacyclin and other mechanisms are also involved. This vascular effect follows binding to two receptors, VEGF receptor 1
Sophie Nadeau, Thérèse Perreault, Johanne Baribeau, Annie Janvier   +3 more
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Vascular Endothelial Growth Factor Signaling

2005
Vascular endothelial growth factor (VEGF) is the main driving force for angiogenesis and vasculogenesis. Identified as a vascular endothelial cell mitogen and survival factor, it has been sequenced and cloned by Ferrara and Connolly in 1989 [74, 84].
Jean-François Dufour, David Semela
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Vascular endothelial growth factors and angiogenesis.

Annales d'endocrinologie, 2000
VEGF was discovered in 1989. Research -conducted over the past 10 years has -demonstrated that VEGF is a major regulator of angiogenesis and vasculogenesis. This paper reviews the molecular data on the multiple forms of VEGF, their signalling and accessory receptors. Five genes encoding VEGF-like proteins have been identified; the different isoforms of
Frelin, C., Ladoux, A., d'Angelo, Gisela
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Growth Factors for Vascular Endothelial Cells

1990
The search for the molecular mediators of growth control in vascular endothelial cells has led to the discovery of a family of endothelial cell growth factors (ECGFs) which differ widely in their ability to trigger endothelial cell proliferation and differentiation in an in vitro or in vivo context.
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Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly  

Vascular Endothelial Growth Factor (VEGF)

2016
One of the best-validated signalling pathways in angiogenesis is vascular endothelial growth factor (VEGF) and its receptors. VEGF family encompasses 7 VEGF glycoproteins members including, VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E and placental growth factors 1 and 2 (PLGF). Of these, the very well-characterized member is VEGF-A. Vascular endothelial
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Treatment of muscle‐invasive and advanced bladder cancer in 2020

Ca-A Cancer Journal for Clinicians, 2020
Vaibhav G Patel, William K Oh, Matthew D Galsky   +2 more
exaly