Results 41 to 50 of about 9,582,351 (290)

Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain

Molecular Pain, 2022
Neuropathic pain is a distressing medical condition with few effective treatments. The role of Vascular endothelial growth factor A (VEGFA) in inflammation pain has been confirmed in many researches.
Zhe Peng, Fan Yang, Siting Huang, Yang Tang, Li Wan   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. [PDF]

, 2008
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension ...
Muttukrishna Shanthi, Muttukrishna, S, Khalil Asma, Khalil, A, Jauniaux, E, Harrington, K, Jauniaux Eric, Kevin Harrington, Harrington Kevin, Shanthi Muttukrishna, Asma Khalil, Eric Jauniaux   +11 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Vascular endothelial growth factor in degenerating intervertebral discs of rat caudal vertebrae

Spine Surgery and Related Research, 2018
Introduction: Discogenic back pain remains poorly understood with respect to etiopathogenesis, despite being a considerable burden. We sought to examine the expression of vascular endothelial growth factor in injured intervertebral discs in rat caudal ...
Jun Sato, Kazuhide Inage, Masayuki Miyagi, Yoshihiro Sakuma, Kazuyo Yamauchi, Masahiko Suzuki, Masao Koda, Takeo Furuya, Junichi Nakamura, Yawara Eguchi, Miyako Suzuki, Go Kubota, Yasuhiro Oikawa, Takeshi Sainoh, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori, Sumihisa Orita   +24 more
doaj   +1 more source

Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment. [PDF]

PLoS ONE, 2013
There is much evidence that hypoxia in the tumor microenvironment enhances tumor progression. In an earlier study, we reported abnormal phenotypes of tumor-associated endothelial cells such as those resistant to chemotherapy and chromosomal instability ...
Miyako Kondoh, Noritaka Ohga, Kosuke Akiyama, Yasuhiro Hida, Nako Maishi, Alam Mohammad Towfik, Nobuo Inoue, Masanobu Shindoh, Kyoko Hida   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Generation of human adult mesenchymal stromal/stem cells expressing defined xenogenic vascular endothelial growth factor levels by optimized transduction and flow cytometry purification [PDF]

, 2012
Adult mesenchymal stromal/stem cells (MSCs) are a valuable source of multipotent progenitors for tissue engineering and regenerative medicine, but may require to be genetically modified to widen their efficacy in therapeutic applications.
Melly, L., Arnaud Scherberich, Ludovic Melly, Wolff, T., Michael Heberer, Heberer, Michael, Marsano, Anna, Banfi, Andrea, Scherberich, Arnaud, Liliane Christ, Andrea Banfi, Helmrich, Uta, Martin, Ivan, Wolff, Thomas, Christ, L., Christ, Liliane, Helmrich, U., Scherberich, A., Anna Marsano, Marsano, A., Melly, Ludovic, Uta Helmrich, Ivan Martin, Martin, I., Heberer, M., Banfi, A., Thomas Wolff   +26 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Vascular endothelial growth factor A promotes platelet adhesion to collagen IV and causes early brain injury after subarachnoid hemorrhage

Neural Regeneration Research, 2019
The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear.
Zun-Wei Liu, Jun-Jie Zhao, Hong-Gang Pang, Jin-Ning Song   +3 more
doaj   +1 more source