Cardiotoxicity with vascular endothelial growth factor inhibitor therapy [PDF]
, 2018 Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway (VSP) have been important additions in the therapy of various cancers, especially renal cell carcinoma and colorectal cancer.
Herrmann, Joerg, Touyz, Rhian M.
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Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro. [PDF]
, 2016 Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease.
Bhutani, Srishti +8 more
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VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8 [PDF]
, 2016 Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses ...
Adhikari +30 more
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Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling.
Liheng Shi +12 more
doaj +1 more source
VEGF is indirectly associated with NO production
, 2012 Background? Increased levels of vascular endothelial growth factor (VEGF) have been observed in patients with metabolic syndrome (MetS). Nitric oxide (NO) formation is reduced in MetS, but its relationship to VEGF production remains poorly defined.
Alberti +28 more
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Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]
, 2017 The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M +9 more
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Molecular Pain, 2022 Neuropathic pain is a distressing medical condition with few effective treatments. The role of Vascular endothelial growth factor A (VEGFA) in inflammation pain has been confirmed in many researches.
Zhe Peng +4 more
doaj +1 more source
Vascular Endothelial Growth Factor Concentration in Brain of Rat Treated with Anaerobic Exercises [PDF]
, 2015 Anaerobic exercise is a high-intensity exercise that needs quick energy supplies obtained in a very short time. However, this exercise may result in tissue hypoxia which is characterized by the increase of HIF-1α concentration.
Ardi, Y. (Yuliana) +7 more
core
Use of intravitreal bevacizumab in a patient with a Von Hippel-Lindau-associated retinal haemangioblastoma of the optic nerve head: a case report [PDF]
, 2008 Introduction The optimum management of a capillary haemangioblastoma affecting the optic nerve head is not clear. A number of treatment modalities have been used to treat the tumours and their consequences.
Timothy A. de Klerk +10 more
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Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle +5 more
wiley +1 more source