Results 111 to 120 of about 3,228,182 (380)

Anti-VEGF drugs compared with laser photocoagulation for the treatment of proliferative diabetic retinopathy: a systematic review and individual participant data meta-analysis

Health Technology Assessment
Background Proliferative diabetic retinopathy is a major cause of sight loss in people with diabetes, with a high risk of vitreous haemorrhage, tractional retinal detachment and other complications.
Mark Simmonds, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Matthew Walton, Rob Hodgson, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, João Pereira Figueira, Sobha Sivaprasad, John G Lawrenson, Tunde Peto, David Steel   +14 more
doaj   +1 more source

Endothelial Dysfunction in Breast Cancer In-Vivo Model

Proceedings, 2018
Although the endothelial dysfunction is related with tumor development, there is no consensus on the suppressive or supportive effect on tumor growth. The goal of the present study was to evaluate endothelial dysfunction related factors in animal breast ...
Buğra Elkar, Mustafa Barış, Meryem Çalışır, Yasemin Çakır, Safiye Aktaş, Merve Tütüncü, M. Kürşat Şimşek, Mustafa Seçil, Osman Yılmaz, Zekiye Altun   +9 more
doaj   +1 more source

Vascular endothelial growth factor-A level in human breast milk after intravitreal injection of ranibizumab: a case report

International Breastfeeding Journal, 2022
Background Ranibizumab is one of intravitreal anti-vascular endothelial growth factor agents. It is applied in the treatments of choroidal neovascularization, age-related macular degeneration, diabetic macular edema, and macular edema secondary to ...
Ying Huang, Rong Zhou, Zuhua Sun, Yihan Zheng, Bing Lin   +4 more
doaj   +1 more source

Integrative modeling of sprout formation in angiogenesis: coupling the VEGFA-Notch signaling in a dynamic stalk-tip cell selection [PDF]

arXiv, 2016
During angiogenesis, new blood vessels headed by a migrating endothelial tip cell sprout from pre-existing ones. This process is known to be regulated by two signaling pathways concurrently, vascular endothelial growth factor A (VEGFA) and Notch-Delta. Extracellular VEGFA activates the intracellular Notch-Delta pathway in nearby endothelial cells which
arxiv  

Vascular endothelial growth factor signaling in development and disease [PDF]

Development, 2018
ABSTRACT Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind to their cognate tyrosine kinase VEGF receptors (VEGFRs) in endothelial cells to elicit various ...
Sinem Karaman, Veli-Matti Leppänen, Kari Alitalo   +2 more
openaire   +4 more sources

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Role of vascular endothelial growth factor receptors in the pathogenesis of psoriasis [PDF]

, 2015
Background : Psoriasis is a chronic immune-inflammatory-mediated disease characterized by epidermal hyperplasia and angiogenesis. Recently, vascular endothelial growth factor receptors (VEGFRs, including VEGFR-1, VEGFR-2 and VEGFR-3) were found to be ...
Hadi Al-Wakeel, Hadi Abed
core   +1 more source

Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma [PDF]

To investigate the clinical significance of circulating angiogenic factors, especially in association with early relapse of osteosarcoma, we quantified pre-therapeutic levels of vascular endothelial growth factor, basic fibroblast growth factor and ...
A Dietz, AM Goorin, C Chao, C Kuhnen, CB Pratt, F Eilber, F Higashino, F Okada, FR Eliber, G Ayala, G Rosen, H Hiraga, H Kumar, HF Dvorak, I Hara, I Hyodo, J Folkman, J Folkman, J Folkman, J Folkman, J Kandel, JK Lee, K Isu, K Jin-no, K Yudoh, KK Smith-McCune, M Edgren, M Kaya, M Kaya, M Landriscina, M Shindoh, M Tada, MK Oehler, ML George, N Ferrara, N Weidner, N Weidner, NJ Webb, P Macchiarini, P Salven, P Salven, P Salven, RE Banks, RL Souhami, S Ishii, S Kawaguchi, S Kawauchi, S Nagoya, S Yamawaki, T Wada, T Wada, T Yamashita, T Yoshikawa, WH Meyer, Y Abe, Y Takahashi, YH Lee   +56 more
core   +2 more sources

Vascular complications of cancer chemotherapy [PDF]

, 2015
Development of new anticancer drugs has resulted in improved mortality rates and 5-year survival rates in patients with cancer. However, many of the modern chemotherapies are associated with cardiovascular toxicities that increase cardiovascular risk in ...
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Evaluation of vascular endothelial growth factor A and leukemia inhibitory factor expressions at the time of implantation in diabetic rats following treatment with Metformin and Pioglitazone [PDF]

, 2020
Background: Implantation requires intimate crosstalk between the embryo and uterus for a successful establishment of pregnancy. Type 2 diabetes mellitus may lead to implantation failure. The effect of diabetes and its therapeutic drugs on implantation is
Aboutorabi, Roshanak, Eskandari, Nahid, Nikpour, Parvaneh, Rashidi, Bahman, Zarei, Ronak   +4 more
core   +3 more sources