Results 21 to 30 of about 436,292 (254)

Vascular endothelial growth factor pathway

Pharmacogenetics and Genomics, 2010
Michael L. Maitlanda, Xing Jian Louc, Jacqueline Ramireza, Apurva A. Desaia, Dorit S. Berlinc, Howard L. McLeodb, Ralph R. Weichselbauma, Mark J. Rataina, Russ B. Altmanc, and Teri E. Kleinc aDepartment of Medicine, Section of Hematology/Oncology, University of Chicago, Maryland Avenue, Chicago, Illinois bUNC Institute for Pharmacogenomics and ...
Michael L, Maitland, Xing Jian, Lou, Jacqueline, Ramirez, Apurva A, Desai, Dorit S, Berlin, Howard L, McLeod, Ralph R, Weichselbaum, Mark J, Ratain, Russ B, Altman, Teri E, Klein   +9 more
openaire   +3 more sources

The function of vascular endothelial growth factor

BioFactors, 2009
AbstractVascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration. This review details our current understanding of VEGF signaling and discusses the benefits and unexpected side effects of promising anti ...
Bonnie J, Nieves, Patricia A, D'Amore, Brad A, Bryan   +2 more
openaire   +3 more sources

Development and Validation of a Vascular Endothelial Growth Factor A-associated Prognostic Model for Unresectable Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2023
Kun He,* Xinyu Liu,* Zelong Yang Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zelong Yang, Department
He K, Liu X, Yang Z
doaj  

Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment. [PDF]

PLoS ONE, 2013
There is much evidence that hypoxia in the tumor microenvironment enhances tumor progression. In an earlier study, we reported abnormal phenotypes of tumor-associated endothelial cells such as those resistant to chemotherapy and chromosomal instability ...
Miyako Kondoh, Noritaka Ohga, Kosuke Akiyama, Yasuhiro Hida, Nako Maishi, Alam Mohammad Towfik, Nobuo Inoue, Masanobu Shindoh, Kyoko Hida   +8 more
doaj   +1 more source

Vascular endothelial growth factor in relation to the development of hepatocellular carcinoma in hepatitis C virus patients treated by direct-acting antivirals

Egyptian Liver Journal, 2021
Background Hepatocellular carcinoma (HCC) comprises 5.6% of all cancers worldwide representing the sixth most common cancer. It is also the fourth most common cause of cancer-related mortality.
Ahmed Mohamed ElGhandour, Essam Mohamed Bayoumy, Wesam Ahmed Ibrahim, Moataz Mohamed Sayed, Ashraf Bekheet Salama, Nahla Mohamed Teama, Mohamed Magdy Salama   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Immunohistochemical Expression of Vascular Endothelial Growth Factor and Its Correlation With Tumor Grade in Breast Ductal Carcinoma [PDF]

Acta Medica Iranica, 2011
Breast cancer is the most common cause of cancer-related death in female, after lung cancer. Angiogenesis is essential for tumor growth and metastasis; therefore, antiangiogenesis strategies for treatment of cancer are currently an issue of interest. The
Laleh Vahedi Larijani, Roghaieh Moghimpour, Saeid Abediankenari, Ahmadreza Bekhradnia, Farshad Naghshvar, Omid Emadian, Maryam Ghasemi   +6 more
doaj   +2 more sources

Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling.
Liheng Shi, Min Zhao, Colette A. Abbey, Shu‐Huai Tsai, Wankun Xie, Dylan Pham, Samantha Chapman, Kayla J. Bayless, Travis W. Hein, Robert H. Rosa, Michael L. Ko, Lih Kuo, Gladys Y.‐P. Ko   +12 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source