Results 61 to 70 of about 855,799 (394)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx

Brazilian Journal of Otorhinolaryngology, 2015
Introduction: Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor ...
Rodrigo Gonzalez Bonhin, Vanessa Brito Campoy Rocha, Guilherme Machado de Carvalho, Alexandre Caixeta Guimarães, Agrício Nubiato Crespo, Carlos Takahiro Chone, Eliane M.I. Amstalden   +6 more
doaj   +1 more source

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis [PDF]

, 2015
Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer cell–extrinsic PI3K activity, mediated by the p110α isoform of PI3K, contributes in an unexpected way to ...
Angulo Aguado, Ana, Casanovas i Casanovas, Oriol, Friedman, Lori S., Gerhardt, Holger, Graupera i Garcia-Milà, Mariona, Guillermet-Guibert, Julie, Pearce, Wayne, Serra, Helena, Soler, Adriana, Vanhaesebroeck, Bart, Viñals Canals, Francesc   +10 more
core   +1 more source

Vascular endothelial growth factor signaling in development and disease

Development, 2018
Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems.
Sinem Karaman, V. Leppänen, K. Alitalo
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Vascular Endothelial Growth Factor [PDF]

Circulation Research, 2000
In this issue of Circulation Research , D’Arcangelo et al1 report highly interesting and unexpected results in that acidosis inhibits proliferation and migration of cultured endothelial cells, inhibits the formation of capillary tubes, but simultaneously increases expression of the endothelial growth factors vascular endothelial growth factor (VEGF ...
Matthias Clauss, Wolfgang Schaper
openaire   +1 more source

Increased expression of adenosine 2A receptors in metastatic renal cell carcinoma is associated with poorer response to anti-vascular endothelial growth factor agents and anti-PD-1/Anti-CTLA4 antibodies and shorter survival [PDF]

, 2021
Takao Kamai, Toshiki Kijima, Toyonori Tsuzuki, Akinori Nukui, Hideyuki Abe, Kyoko Arai, Ken‐Ichiro Yoshida   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis

Health Technology Assessment
Background Diabetic retinopathy is a major cause of sight loss in people with diabetes, with a high risk of macular oedema, vitreous haemorrhage or other complications.
Mark Simmonds, Matthew Walton, Rob Hodgson, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John Lawrenson, Tunde Peto, David Steel   +12 more
doaj   +1 more source

Vascular Endothelial Growth Factor (VEGF) and Platelet (PF-4) Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context [PDF]

, 2013
The process of angiogenesis is under complex regulation in adult organisms, particularly as it often occurs in an inflammatory post-wound environment. As such, there are many impacting factors that will regulate the generation of new blood vessels which ...
Adair, Aidoudi, Anastasiadis, Balasubramaniam, Ban, Barrientos, Beauchamp, Bernardini, Bodnar, Bodnar, Brantley-Sieders, Calalb, Campbell, Carmeliet, Carmeliet, Cheng, Chiu, Chung, Dephoure, Eminaga, Fang, Feil, Frey, Fujiwara, George, Gillitzer, Gupta, Hendrix, Hess, Hu, Hu, Huang, Jackson, Kanaji, Kasper, Kaully, Kawauchi, Keeley, Kikawa, Kim, Kirkpatrick, Kobayashi, Kundu, Larsen, Lee, Lim, Liu, Matozaki, Matsui, Mayya, Mehrad, Mendes, Miao, Miao, Miao, Mortensen, Naegle, Newman, Nichols, Noberini, Noberini, Norbury, O'Meara, Pasquale, Patrussi, Perkins, Perretti, Petrai, Platt, Poliakov, Potapova, Radke, Raingeaud, Ravichandran, Ren, Rimchala, Romanova, Rosenkilde, Roux, Saharinen, Sahota, Salcedo, Shao, Sherwood, Shikata, Shults, Singh, Slungaard, Soker, Sotirellis, Spangler, Squire, Su, Sulpice, Szekanecz, Tabruyn, Tcatchoff, Thalhammer, Tremper-Wells, Tsubouchi, Vandercappellen, Vandercappellen, Vindis, Vizcaíno, Walker-Daniels, Welburn, Werdich, Werner, Wykosky, Yancopoulos, Yi, Zhang, Zhang, Zhao   +113 more
core   +1 more source