Results 81 to 90 of about 932,558 (375)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Angiogenic Factors produced by Hypoxic Cells are a leading driver of Anastomoses in Sprouting Angiogenesis---a computational study [PDF]

Scientific Reports volume 8, Article number: 8726 (2018), 2018
Angiogenesis - the growth of new blood vessels from a pre-existing vasculature - is key in both physiological processes and on several pathological scenarios such as cancer progression or diabetic retinopathy. For the new vascular networks to be functional, it is required that the growing sprouts merge either with an existing functional mature vessel ...
arxiv   +1 more source

Gene Transfers of Vascular Endothelial Growth Factor-A, Vascular Endothelial Growth Factor-B, Vascular Endothelial Growth Factor-C, and Vascular Endothelial Growth Factor-D Have No Effects on Atherosclerosis in Hypercholesterolemic Low-Density Lipoprotein-Receptor/Apolipoprotein B48-Deficient Mice [PDF]

Circulation, 2005
Background— The role of vascular endothelial growth factors (VEGFs) in large arteries has been proposed to be either vasculoprotective or proatherogenic. Because VEGF family members are used for human therapy, it is important to know whether they could enhance atherogenesis.
Seppo Ylä-Herttuala, Jonna Koponen, Kari Alitalo, Christina Fieber, Suvi Koota, Ivana Kholová, Ulf Eriksson, Pia Leppänen   +7 more
openaire   +3 more sources

Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.

European Journal of Biochemistry, 2000
Vascular endothelial growth factor-D (VEGF-D), the most recently discovered mammalian member of the VEGF family, is an angiogenic protein that activates VEGF receptor-2 (VEGFR-2/Flk1/KDR) and VEGFR-3 (Flt4).
M. G. Achen, S. Roufail, T. Domagala, B. Catimel, E. Nice, D. Geleick, R. Murphy, A. Scott, C. Caesar, T. Makinen, K. Alitalo, S. Stacker   +11 more
semanticscholar   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

VEGF-C inhibits Kupffer cells activation and alleviates ischemia-reperfusion injury in rats after liver transplantation

Di-san junyi daxue xuebao, 2019
Objective To investigate whether vascular endothelial growth factor receptor-3 (VEGFR-3)/VEGF-C signaling suppresses activation of Kupffer cells (KCs) and attenuates hepatic ischemia-reperfusion injury (IRI) after liver transplantation.
CHENG Mingxiang, LI Jinzheng, CHEN Yong
doaj   +1 more source

Human keratinocytes express the three major splice forms of vascular endothelial growth factor.

Journal of Investigative Dermatology, 1995
Vascular endothelial growth factor is a powerful mitogen for endothelial cells, recently reported to be produced by keratinocytes. In the present work, we examined human keratinocytes in primary culture for the splice variants of vascular endothelial ...
C. Ballaun, W. Weninger, A. Uthman, H. Weich, E. Tschachler   +4 more
semanticscholar   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Expression of hypoxia inducible factor-1α and vascular endothelial growth factor-C in human chronic periodontitis

Journal of Dental Sciences, 2015
Background/purpose: Evidence shows that there is a relationship between hypoxia and inflammatory response in periodontitis. Hypoxia-inducible factor (HIF)-1α is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress ...
Qing-Yan Shi, Shi-Guang Huang, Jing-Hua Zeng, Xiao-Guo Fang   +3 more
doaj   +1 more source

Expression of vascular endothelial growth factors A and C in human pancreatic cancer

World Journal of Gastroenterology, 2006
To study the expression of vascular endothelial growth factor A (VEGF-A) and VEGF-C and to determine whether the presence of VEGF-A and VEGF-C was associated with the clinicopathologic characteristics of pancreatic cancer.VEGF-A and VEGF-C mRNA transcripts were examined by Northern blot in 6 human pancreatic cancer cell lines and 8 normal pancreatic ...
Shun-Xiang Wang, Zhi-Feng Li, Li Peng, Shu-Xia Wang, Feng-Rui Zhang, Yan Xiao, Meng Zhang, Rui-Feng Tang, Zhi-Ming Zhang   +8 more
openaire   +3 more sources