Results 81 to 90 of about 28,223,317 (305)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Expression of hypoxia inducible factor-1α and vascular endothelial growth factor-C in human chronic periodontitis

Journal of Dental Sciences, 2015
Background/purpose: Evidence shows that there is a relationship between hypoxia and inflammatory response in periodontitis. Hypoxia-inducible factor (HIF)-1α is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress ...
Qing-Yan Shi, Shi-Guang Huang, Jing-Hua Zeng, Xiao-Guo Fang   +3 more
doaj   +1 more source

Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]

, 2010
Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren, Koh, Chester J., Aguilar Berenice, Yoo, Jaehyuk, Hong Young-Kwon, Hong, Young-Kwon, Lee, Sunju, Choi, Inho, Yoo Jaehyuk, Haas, Jürgen G., Kang Jinjoo, Lee Ha Neul, Swapnika Ramu, Kang, Jinjoo, Young-Kwon Hong, Juneyong Lee, Ramu, Swapnika, Darren Kafka, Lee, Juneyong, Kafka Darren, Lee Sunju, Choi Inho, Juergen Haas, Haas, Juergen, Lee Juneyong, Sunju Lee, Inho Choi, Ha Neul Lee, Haas Juergen, Aguilar, Berenice, Chester J. Koh, Jinjoo Kang, Chester J Koh, Jaehyuk Yoo, Koh Chester J., Berenice Aguilar, Ramu Swapnika, Lee, Ha Neul   +37 more
core   +1 more source

The Proteolytic Activation of Vascular Endothelial Growth Factor-­C

, 2019
English version of the review "Die proteolytische Aktivierung des Vaskulären Endothelzellwachstumsfaktors-C."
Lackner, Marcel, Schmotz, Constanze, Jeltsch, Michael   +2 more
openaire   +2 more sources

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

VEGF-C inhibits Kupffer cells activation and alleviates ischemia-reperfusion injury in rats after liver transplantation

Di-san junyi daxue xuebao, 2019
Objective To investigate whether vascular endothelial growth factor receptor-3 (VEGFR-3)/VEGF-C signaling suppresses activation of Kupffer cells (KCs) and attenuates hepatic ischemia-reperfusion injury (IRI) after liver transplantation.
CHENG Mingxiang, LI Jinzheng, CHEN Yong
doaj   +1 more source

Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein [PDF]

Circulation Research, 2007
Vascular endothelial growth factor (VEGF)-C and VEGF-D require proteolytic cleavage of the carboxy terminal silk-homology domain for activation. To study the functions of the VEGF-C propeptides, we engineered a chimeric growth factor protein, VEGF-CAC, composed of the amino- and carboxy-terminal propeptides of VEGF-C fused to the receptor-activating ...
Salla, Keskitalo, Tuomas, Tammela, Johannes, Lyytikka, Terhi, Karpanen, Michael, Jeltsch, Johanna, Markkanen, Seppo, Yla-Herttuala, Kari, Alitalo   +7 more
openaire   +2 more sources

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate, Plate, Karl, Wittko-Schneider, Ina M., Schneider, Fabian T., Fabian T. Schneider, Ina M. Wittko-Schneider   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics [PDF]

, 2014
Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the functions of
Reyes-Aldasoro, Constantino C., Steele, A.J., Constantino C Reyes-Aldasoro, Harris Sheila, English William R., English, W. R., Kanthou, Chryso, Diane V Lefley, Reyes-Aldasoro, C.C., Sheila Harris (77307), Reyes-Aldasoro Constantino C., Lefley, D. V., Dos Santos, S. A., Andrew J Steele, English, William R., Dachs, G. U., English, W.R., Steele Andrew J., Sheila Harris, Dachs Gabi U., Greco, Olga, Gillian M. Tozer (167783), Claudia Coralli-Foxon, Kanthou Chryso, Reyes-Aldasoro, C. C., William R English, Steele, Andrew J., Tozer, G. M., Gabi U Dachs, Coralli-Foxon, Claudia, Olga Greco (614634), Harris, S., Olga Greco, Andrew J. Steele (614632), Sofia A. Dos Santos (614635), Dachs, G.U., Dos Santos, S.A., Claudia Coralli-Foxon (614633), Harris, Sheila, Sofia A Dos Santos, Coralli-Foxon Claudia, Greco Olga, Tozer Gillian M., Chryso Kanthou, Gillian M Tozer, Tozer, Gillian M., William R. English (184202), Dos Santos Sofia A., Kanthou, C., Lefley, Diane V., Dos Santos, Sofia A., Chryso Kanthou (22774), Greco, O., Gabi U. Dachs (614630), Steele, A. J., Lefley, D.V., Diane V. Lefley (614631), Dachs, Gabi U., Constantino C. Reyes-Aldasoro (324791), Lefley Diane V., Coralli-Foxon, C., Tozer, G.M.   +61 more
core   +2 more sources