Results 21 to 30 of about 37,380,162 (289)

Vascular endothelial growth factor receptor 1 in glioblastoma‑associated microglia/macrophages

Oncology Reports, 2020
The anti‑vascular endothelial growth factor‑A (VEGF‑A) monoclonal antibody (mAb) bevacizumab is an FDA‑approved monotherapy for the treatment of recurrent glioblastoma (GB), a highly angiogenic and infiltrative tumour. However, bevacizumab does not increase overall survival and blockade of VEGF‑A/VEGF receptor (VEGFR)‑2 signal transduction is ...
Lisi L., Ciotti G. M. P., Chiavari M., Ruffini F., Lacal P. M., Graziani G., Navarra P.   +6 more
openaire   +4 more sources

Vascular Endothelial Growth Factor Receptor-1 and Neuropilin-2 Form Complexes [PDF]

Journal of Biological Chemistry, 2001
The products of the neuropilin-1 (Np-1) and neuropilin-2 (Np-2) genes are receptors for factors belonging to the class 3 semaphorin family and participate in the guidance of growing axons to their targets. In the presence of heparin-like molecules, both receptors also function as receptors for the heparin-binding 165-amino acid isoform of vascular ...
Z, Gluzman-Poltorak, T, Cohen, M, Shibuya, G, Neufeld   +3 more
openaire   +2 more sources

Novel Function for Vascular Endothelial Growth Factor Receptor-1 on Epidermal Keratinocytes [PDF]

The American Journal of Pathology, 2005
Vascular endothelial growth factor (VEGF-A), a potent stimulus for angiogenesis, is up-regulated in the skin after wounding. Although studies have shown that VEGF is important for wound repair, it is unclear whether this is based solely on its ability to promote angiogenesis or if VEGF can also promote healing by acting directly on non-endothelial cell
Traci A, Wilgus, Annette M, Matthies, Katherine A, Radek, Julia V, Dovi, Aime L, Burns, Ravi, Shankar, Luisa A, DiPietro   +6 more
openaire   +2 more sources

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]

, 2001
Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Losa, Marco, Lohrer, P., Gloddek, J., Renner, U., Lohrer, Penny, Uhl, E., Stalla, G., Pagotto, U., Hopfner, Ursula, Renner, Ulrich, Losa, Marc, Losa, M., Pagotto, Uberto, Gloddek, Jutta, Uhl, Eberhard, Stalla, Günter K., Hopfner, U.   +16 more
core   +1 more source

Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling

Autophagy Reports, 2023
Pharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging.
Pierre-Louis Tharaux, Olivia Lenoir
doaj   +1 more source

Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms [PDF]

Circulation, 2009
Background— New revascularization therapies are urgently needed for patients with severe coronary heart disease who lack conventional treatment options. Methods and Results— We describe a new proangiogenic approach for these no-
Johanna E, Lähteenvuo, Markku T, Lähteenvuo, Antti, Kivelä, Carolina, Rosenlew, Annelie, Falkevall, Joakim, Klar, Tommi, Heikura, Tuomas T, Rissanen, Elisa, Vähäkangas, Petra, Korpisalo, Berndt, Enholm, Peter, Carmeliet, Kari, Alitalo, Ulf, Eriksson, Seppo, Ylä-Herttuala   +14 more
openaire   +2 more sources

CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma. [PDF]

, 2012
The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we
Jellbauer, Stefan, Hetrodt, Justin H., Justin H Hetrodt, Rüssmann, Holger, Stefan Jellbauer, Klaus Panthel, Holger Rüssmann, Panthel, Klaus   +7 more
core   +2 more sources

Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial

Tumor Biology, 2017
Despite initial responsiveness, acquired resistance to both bevacizumab and chemotherapy in metastatic colorectal cancer is universal. We have recently published that in vitro, chronically oxaliplatin resistance upregulates soluble vascular endothelial ...
Estela Pineda, A Salud, E Vila-Navarro, MJ Safont, Beatriz Llorente, J Aparicio, R Vera, P Escudero, E Casado, C Bosch, U Bohn, R Pérez-Carrión, A Carmona, JR Ayuso, T Ripollés, R Bouzas, M Gironella, X García-Albéniz, J Feliu, J Maurel   +19 more
doaj   +1 more source

Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. [PDF]

PLoS ONE, 2017
Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however, participation of vascular endothelial growth factor (VEGF) and its receptors in this placental adaptation is unclear.
Felipe Troncoso, Jesenia Acurio, Kurt Herlitz, Claudio Aguayo, Patricio Bertoglia, Enrique Guzman-Gutierrez, Marco Loyola, Marcelo Gonzalez, Meriem Rezgaoui, Gernot Desoye, Carlos Escudero   +10 more
doaj   +1 more source