Results 31 to 40 of about 331,972 (306)

Dynamic soluble changes in sVEGFR1, HGF, and VEGF promote chemotherapy and bevacizumab resistance: A prospective translational study in the BECOX (GEMCAD 09-01) trial

Tumor Biology, 2017
Despite initial responsiveness, acquired resistance to both bevacizumab and chemotherapy in metastatic colorectal cancer is universal. We have recently published that in vitro, chronically oxaliplatin resistance upregulates soluble vascular endothelial ...
Estela Pineda, A Salud, E Vila-Navarro, MJ Safont, Beatriz Llorente, J Aparicio, R Vera, P Escudero, E Casado, C Bosch, U Bohn, R Pérez-Carrión, A Carmona, JR Ayuso, T Ripollés, R Bouzas, M Gironella, X García-Albéniz, J Feliu, J Maurel   +19 more
doaj   +1 more source

Serum Vascular Endothelial Growth Factor/Soluble Vascular Endothelial Growth Factor Receptor 1 Ratio Is an Independent Prognostic Marker in Pancreatic Cancer [PDF]

Pancreas, 2008
Tumor angiogenesis is the consequence of an imbalance between positive and negative angiogenic regulatory factors. We sought to determine the role of pretreated serum angiogenic factors, including vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), in ...
Chang, Yu-Ting, Chang, Ming-Chu, Wei, Shu-Chen, Tien, Yu-Wen, Hsu, Chiun, Liang, Po-Chin, Tsao, Po-Nien, Jan, I-Shiow, Wong, Jau-Min   +8 more
openaire   +3 more sources

VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process

BMC Research Notes, 2018
Objective During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth ...
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V. Stoyanov   +5 more
doaj   +1 more source

CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma. [PDF]

, 2012
The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we
Jellbauer, Stefan, Hetrodt, Justin H., Justin H Hetrodt, Rüssmann, Holger, Stefan Jellbauer, Klaus Panthel, Holger Rüssmann, Panthel, Klaus   +7 more
core   +1 more source

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Shima, D., Christiana Ruhrberg, Betsholtz, C, Jeltsch, M, Abramsson, A., Shima, D, Matthew Golding, Lundkvist, A, Lundkvist, A., Golding, M, David Shima, Ruhrberg, C, Christopher Mitchell, Mitchell, C, Betsholtz, C., Kari Alitalo, Gerhardt, H, Ruhrberg, C., Christer Betsholtz, Golding, M., Jeltsch, M., Holger Gerhardt, Abramsson, A, Alitalo, K, Andrea Lundkvist, Fruttiger, M., Gerhardt, H., Alitalo, K., Alexandra Abramsson, Mitchell, C., Fruttiger, M, Michael Jeltsch, Marcus Fruttiger   +32 more
core   +1 more source

Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma

Acta Dermato-Venereologica, 2019
To shed more light on the pathogenesis of sebaceous carcinoma, we analysed the expression of proteins related to angiogenesis in 18 ocular and 22 extraocular sebaceous carcinomas using a broad panel of immunohistochemical markers.
Ferdinand Toberer, Holger A. Haenssle, Arno Rütten, Dmitry Kazakov, Liubov Kastnerova, Alexander Enk, Wolfgang Hartschuh, Ines Bertlich, Julia Hartmann, Martin Laimer, Wolfgang Weyers, Peter Helmbold, Heinz Kutzner   +12 more
doaj   +1 more source

Endothelial Dysfunction in Breast Cancer In-Vivo Model

Proceedings, 2018
Although the endothelial dysfunction is related with tumor development, there is no consensus on the suppressive or supportive effect on tumor growth. The goal of the present study was to evaluate endothelial dysfunction related factors in animal breast ...
Buğra Elkar, Mustafa Barış, Meryem Çalışır, Yasemin Çakır, Safiye Aktaş, Merve Tütüncü, M. Kürşat Şimşek, Mustafa Seçil, Osman Yılmaz, Zekiye Altun   +9 more
doaj   +1 more source

Soluble Vascular Endothelial Growth Factor Receptor 1 in Human Breast Milk

Hormone Research in Paediatrics, 2011
<i>Background/Aims:</i> Vascular endothelial growth factor (VEGF) is a potent proangiogenic protein that activates VEGF receptor (VEGFR-1, VEGFR-2) tyrosine kinases expressed by vascular endothelial cells. A soluble truncated form of VEGFR-1 (sVEGFR-1) binds to VEGF as strongly as full-length VEGFR-1 and inhibits VEGF activity. sVEGFR-1 can
Ozgurtas, Taner, Aydin, Ibrahim, Turan, Ozden, Koc, Esin, Hirfanoglu, Ibrahim M., Acikel, Cengiz H., Akyol, Mesut, Serdar, Muhittin, Erbil, Kemal M.   +8 more
openaire   +5 more sources

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate, Plate, Karl, Wittko-Schneider, Ina M., Schneider, Fabian T., Fabian T. Schneider, Ina M. Wittko-Schneider   +5 more
core   +1 more source

Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment. [PDF]

PLoS ONE, 2013
There is much evidence that hypoxia in the tumor microenvironment enhances tumor progression. In an earlier study, we reported abnormal phenotypes of tumor-associated endothelial cells such as those resistant to chemotherapy and chromosomal instability ...
Miyako Kondoh, Noritaka Ohga, Kosuke Akiyama, Yasuhiro Hida, Nako Maishi, Alam Mohammad Towfik, Nobuo Inoue, Masanobu Shindoh, Kyoko Hida   +8 more
doaj   +1 more source