Results 191 to 200 of about 650,658 (370)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Novel hKDR mouse model depicts the antiangiogenesis and apoptosis-promoting effects of neutralizing antibodies targeting vascular endothelial growth factor receptor 2. [PDF]

Cancer Sci, 2023
Cao Y, Sun C, Huo G, Wang H, Wu Y, Wang F, Liu S, Zhai S, Zhang X, Zhao H, Hu M, Gu W, Yang Y, Wang S, Liang C, Lyu J, Lu T, Wang Y, Xie L, Fan C.   +19 more
europepmc   +1 more source

Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H₂ receptors [PDF]

, 2001
Ajoy Kumar Ghosh, Noriyasu Hirasawa, Kazuo Ohuchi   +2 more
openalex   +1 more source

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Decreases in GSH:GSSG activate vascular endothelial growth factor receptor 2 (VEGFR2) in human aortic endothelial cells

Redox Biology, 2018
The angiogenic capacity of local tissue critically regulates the response to ischemic injury. Elevated reactive oxygen species production, commonly associated with ischemic injury, has been shown to promote phosphorylation of the vascular endothelial ...
Priya K. Prasai, Bandana Shrestha, A. Wayne Orr, Christopher B. Pattillo   +3 more
doaj  

Vascular Endothelial Growth Factor A (VEGF-A) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) as Potential Biomarkers for Oral Squamous Cell Carcinoma: A Sri Lankan Study. [PDF]

Asian Pac J Cancer Prev, 2023
Edirisinghe ST, Weerasekera M, De Silva DK, Devmini MT, Pathmaperuma S, Wijesinghe GK, Nisansala T, Maddumage A, Huzaini H, Rich AM, De Silva H, Trudy M, Goonasinghe R, De Silva K, Yasawardena S.   +14 more
europepmc   +1 more source

Vascular Endothelial Cell Growth Factor-Driven Endothelial Tube Formation Is Mediated by Vascular Endothelial Cell Growth Factor Receptor-2, a Kinase Insert Domain-Containing Receptor [PDF]

, 2001
Suya Yang, Xiaohua Xin, Constance Zlot, Gladys S. Ingle, Germaine Fuh, Bing Li, Barbara Moffat, Abraham M. de Vos, Mary E. Gerritsen   +8 more
openalex   +1 more source

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis

Advanced Healthcare Materials, EarlyView.
Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu, Joel M. Yong, Robyn Yeh, Florence Bartlett, John M. Whitelock, Megan S. Lord   +5 more
wiley   +1 more source

Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis. [PDF]

Immunity, 2023
Fu T, Sullivan DP, Gonzalez AM, Haynes ME, Dalal PJ, Rutledge NS, Tierney AL, Yescas JA, Weber EW, Muller WA.   +9 more
europepmc   +1 more source

Reactive Oxygen Species as Downstream Mediators of Angiogenic Signaling by Vascular Endothelial Growth Factor Receptor-2/KDR [PDF]

, 2002
Renata Colavitti, Giovambattista Pani, Barbara Bedogni, Rosanna Anzevino, Silvia Borrello, Johannes Waltenberger, Tommaso Galeotti   +6 more
openalex   +1 more source