Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling.
Liheng Shi +12 more
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Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. [PDF]
PLoS ONE, 2017 Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however, participation of vascular endothelial growth factor (VEGF) and its receptors in this placental adaptation is unclear.
Felipe Troncoso +10 more
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Autophagy Reports, 2023 Pharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging.
Pierre-Louis Tharaux, Olivia Lenoir
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Bridging Scales: a Hybrid Model to Simulate Vascular Tumor Growth and Treatment Response [PDF]
, 2023 Cancer is a disease driven by random DNA mutations and the interaction of many complex phenomena. To improve the understanding and ultimately find more effective treatments, researchers leverage computer simulations mimicking the tumor growth in silico.
arxiv +1 more source
Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties [PDF]
Acta Biomaterialia 86, 441-449 (2019), 2021 3D porous scaffolds based on agarose and nanocrystalline apatite, two structural components that act as a temporary mineralized extracellular matrix, were prepared by the GELPOR3D method. This shaping technology allows the introduction of thermally-labile molecules within the scaffolds during the fabrication procedure.
arxiv +1 more source
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro [PDF]
PLoS Comput Biol 10(8): e1003774, 2014, 2013 In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an extracellular matrix, endothelial cells can form blood vessel-like structures, including vascular networks and sprouts.
arxiv +1 more source
Vascular Endothelial Growth Factor–Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth [PDF]
Cancer Research, 2008 Abstract Vascular endothelial growth factor (VEGF) is a potent proangiogenic protein that activates VEGF receptor (VEGFR) tyrosine kinases expressed by vascular endothelial cells. We previously showed that one of these receptors, VEGFR-2, has a truncated soluble form (sVEGFR-2) that can be detected in mouse and human plasma.
Giulio Francia +9 more
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Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma
Acta Dermato-Venereologica, 2019 To shed more light on the pathogenesis of sebaceous carcinoma, we analysed the expression of proteins related to angiogenesis in 18 ocular and 22 extraocular sebaceous carcinomas using a broad panel of immunohistochemical markers.
Ferdinand Toberer +12 more
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Endothelial Dysfunction in Breast Cancer In-Vivo Model
Proceedings, 2018 Although the endothelial dysfunction is related with tumor development, there is no consensus on the suppressive or supportive effect on tumor growth. The goal of the present study was to evaluate endothelial dysfunction related factors in animal breast ...
Buğra Elkar +9 more
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Neural Regeneration Research, 2019 The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear.
Zun-Wei Liu +3 more
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