Results 11 to 20 of about 10,357,485 (302)

Signaling via Vascular Endothelial Growth Factor Receptors

Experimental Cell Research, 1999
Angiogenesis, or development of blood vessels from preexisting vasculature, has important functions under both normal and pathophysiological conditions. Vascular endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic responses ...
T V, Petrova, T, Makinen, K, Alitalo
openaire   +3 more sources

Vascular Targeted Agents for the Treatment of Angiosarcoma [PDF]

, 2013
Background: Angiogenesis is the process of new blood vessel formation, and is regulated by angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiosarcomas are rare, aggressive vascular tumours.
P J Woll (16226153), R J Young (13425891), C A Staton (16226156), Malcolm Reed (4465876), Young, Robin, N J Brown (13424178)   +5 more
core   +5 more sources

Signal transduction by vascular endothelial growth factor receptors. [PDF]

Cold Spring Harb Perspect Med, 2012
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs).
Koch S, Claesson-Welsh L.
europepmc   +4 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers. [PDF]

Mol Oncol
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
David M, Karaulic A, Bennetot A, Fournier C, Odet Q, Gouraud A, Bourget I, Gaggioli C, Giuliano S, Luciano F, Léger O, Sellam Z, Pagès G.   +12 more
europepmc   +2 more sources

Intraluminal application of vascular endothelial growth factor enhances healing of microvascular anastomosis in a rat model [PDF]

, 2005
Background: Early reconstitution after injury to the endothelium is an important feature for reducing a number of vessel wall pathologies. We investigated the effect of vascular endothelial growth factor ( VEGF) and its impact on the vascular remodeling ...
Hollenberg, S. M., Shakibaei, M., Kossmehl, P., Faramarzi, S., Paul, M., Schulze-Tanzil, G., Infanger, M., Grosse, J., Grimm, D.   +8 more
core   +1 more source

Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]

, 2001
Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Losa, Marco, Lohrer, P., Gloddek, J., Renner, U., Lohrer, Penny, Uhl, E., Stalla, G., Pagotto, U., Hopfner, Ursula, Renner, Ulrich, Losa, Marc, Losa, M., Pagotto, Uberto, Gloddek, Jutta, Uhl, Eberhard, Stalla, Günter K., Hopfner, U.   +16 more
core   +1 more source

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate, Plate, Karl, Wittko-Schneider, Ina M., Schneider, Fabian T., Fabian T. Schneider, Ina M. Wittko-Schneider   +5 more
core   +1 more source

Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. [PDF]

PLoS ONE, 2011
We identified that the angiotensin receptor antagonist, candesartan, has profound neurovascular protective properties when administered after ischemic stroke and was associated with a proangiogenic state at least partly explained by vascular endothelial ...
Weihua Guan, Payaningal R Somanath, Anna Kozak, Anna Goc, Azza B El-Remessy, Adviye Ergul, Maribeth H Johnson, Ahmed Alhusban, Sahar Soliman, Susan C Fagan   +9 more
doaj   +1 more source

Exercise Training Ameliorates The Tramadol-Induced Toxicity on VEGF/VEGFRs/PI3K/AKT Signaling Pathway in Testicular Tissue after Tramadol Withdrawal [PDF]

International Journal of Fertility and Sterility
Background: The study investigated how exercise training protocols (ETPs) with different intensities can amelioratethe tramadol (TRA)-induced toxicity in the testicular tissue by upregulating VEGF/VEGFRs/PI3K/AKT signalingpathway in the post-withdrawal ...
Vahid Saeidifard, Asghar Tofighi, Javad Tolouei Azar, Mazdak Razi   +3 more
doaj   +1 more source

Extrahepatic Angiogenesis: A Potential Common Pathophysiological Basis of Multiple Organ Dysfunction in Rats with Cholestasis Cirrhosis

Frontiers in Bioscience-Landmark, 2023
Background: In addition to intrahepatic angiogenesis, patients with cholestasis cirrhosis develop extrahepatic vasculature disorders and functional disturbances of multiple organ systems.
Dandan Wang, Chunyong Yang, Ziyang Zeng, Xianfeng Wu, Hao Liang, Xiaoyan Hu, Yizhu Sun, Junhong Li, Jun Li, Xin Shu, Zhiyong Yang, Xiaobo Wang, Karine Belguise, Yujie Li, Bin Yi   +14 more
doaj   +1 more source