Results 261 to 270 of about 10,357,485 (302)

Inhibitors of the vascular endothelial growth factor receptor

Hematology/Oncology Clinics of North America, 2002
The inhibitors of VEGF-mediated signaling continue to wind their way through extensive preclinical and clinical development paths. Whereas the first phase III trial did not meet its endpoints, one hopes that the others will. As we learn more about the VEGF pathways in the laboratory and the clinic, we can interpret with greater certainty what role ...
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Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain

Neuroscience, 2015
Increased understanding of the neurovascular niche suggests that development of the central nervous system (CNS) and its vasculature is coordinated through shared regulatory factors. These include the vascular endothelial growth factor (VEGF) family, reported to promote neuroproliferation and neuroprotection in addition to angiogenesis via its ...
M C, Ward, A M, Cunningham
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Immunohistochemical Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor in Canine Cutaneous Fibrosarcomas

Journal of Comparative Pathology, 2009
The expression of five markers associated with tumour angiogenesis, proliferation and apoptosis was studied in 24 canine cutaneous fibrosarcomas. Tumours were assigned histological grades and were immunohistochemically evaluated for the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2 ...
A N, Al-Dissi, D M, Haines, B, Singh, B A, Kidney   +3 more
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Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain

Brain Research, 2002
Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within its developing cerebral cortex. In this study, with the aim of elucidating the mechanisms of vascular involvement during brain impairment in Duchenne muscular distrophy (DMD), we have correlated the ...
NICO, Beatrice, CORSI, Patrizia, RIBATTI, Domenico, VACCA, Angelo, RONCALI L.   +4 more
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Signal transduction by vascular endothelial growth factor receptors

Biochemical Society Transactions, 2003
Vascular endothelial growth factor (VEGF)/vascular permeability factor is the prototype for a growing family of dimeric growth factors, which exert their effects on vascular and lymphatic endothelial cells, as well as on a wide range of other cell types.
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Vascular Endothelial Growth Factor and Type 2 Receptor for This Factor in Vascular Malformations

Bulletin of Experimental Biology and Medicine, 2011
Immunohistochemical study revealed higher level of VEGF expression in vascular malformations compared to that in normal vessels of the adjacent tissue. VEGF expression was slightly higher in the endothelium of arteriovenous angiodysplasias than in venous angiodysplasias.
K A, Pavlov, E S, Gershtein, E A, Dubova, A I, Shchegolev   +3 more
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Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells and a decreased expression of lung vascular endothelial growth factor (VEGF) and its receptor 2 (VEGF R2).
Y, Kasahara, R M, Tuder, C D, Cool, D A, Lynch, S C, Flores, N F, Voelkel   +5 more
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Increased Vascular Endothelial Growth Factor and Receptors

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale Increased vascularity is a feature of airway remodeling in asthma with the potential to contribute to a number of functional abnormalities in this chronic disease. Although various growth factors have been implicated in modulating vascularity, the important contributors in ...
Bryce N. Feltis, Dharshini Wignarajah, Ling Zheng, Chris Ward, David Reid, Richard Harding, E. Haydn Walters   +6 more
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Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis

Critical Reviews in Oncology/Hematology, 2000
Angiogenesis, formation of new vessels from pre-existing ones, results from stimulation of endothelial cells, which line the vessel wall. These cells will leave their resting state and start to digest the basement membrane, proliferate, migrate and eventually differentiate to form a hollow tube. All these steps can be induced by growth factors and this
P, Gerwins, E, Sköldenberg, L, Claesson-Welsh   +2 more
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[Expression of pulmonary vascular endothelial growth factor and vascular endothelial growth factor receptor in emphysema].

Zhonghua nei ke za zhi, 2006
To investigate the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) in lung tissues of emphysema patients.The peripheral lung tissues were obtained from 35 patients undergoing pneumonectomy.
Yue-hong, Wang, Chun-xue, Bai, Ling, Mao, Min, Zhang   +3 more
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