Results 311 to 320 of about 359,258 (362)

Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression

Frontiers in Bioscience, 2007
Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo, Cai, Xiaoyuan, Chen
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Ovarian vascular endothelial growth factor and vascular endothelial growth factor receptor patterns in reproductive aging

Fertility and Sterility, 2008
To investigate how levels of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) change during corpus luteum formation in reproductive aging.Adult and reproductive aging female rats were given pregnant mare serum gonadotropin (PMSG) and the ovaries and sera were collected at 0, 3, 5, and 7 days after human chorionic gonadotropin (hCG ...
John, Yeh, Beom Su, Kim, Jennifer, Peresie   +2 more
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Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung

Critical Care Medicine, 2005
Vascular endothelial growth factor (VEGF) regulates vascular proliferation and causes vasodilation. In the pulmonary circulation, the vasorelaxing effect of VEGF has been attributed to nitric oxide, whereas in other vascular beds, prostacyclin and other mechanisms are also involved. This vascular effect follows binding to two receptors, VEGF receptor 1
Annie, Janvier, Sophie, Nadeau, Johanne, Baribeau, Thérèse, Perreault   +3 more
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Role of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptors in Vascular Development

1999
Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the ...
P, Carmeliet, D, Collen
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Modulation of vascular endothelial growth factor receptors in melanocytes

Experimental Dermatology, 2005
Abstract:  Vascular endothelial growth factor (VEGF) is constitutively produced by keratinocytes, but has no known epidermal target cell. We now report that normal human melanocytes (Mc) maintained in serum‐free, hormone‐, and growth factor‐supplemented medium lacking phorbol ester and choleragen constitutively express VEGF receptor‐1 (VEGFR‐1), VEGFR ...
Ellen J, Kim, Hee-Young, Park, Mina, Yaar, Barbara A, Gilchrest   +3 more
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Angiosarcoma of the breast and vascular endothelial growth factor receptor.

Tumori, 2011
Breast angiosarcoma is rare and often associated with previous breast cancer treatment. The present study aimed to define long-term outcomes in relation to common prognostic factors. The expression of vascular endothelial growth factor receptor was also evaluated, as it may be a potential target for anti-angiogenic therapy.We retrospectively assessed ...
Massimiliano Gennaro, Barbara Valeri, Patrizia Casalini, Maria Luisa Carcangiu, Alessandro Gronchi, Alberto Rudy Conti, Roberto Agresti, Marco Greco   +7 more
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Vascular Endothelial Growth Factor Receptor-3

1999
Cell-cell communication during vascular development and tumour angiogenesis seems to involve at least five endothelial cell-specific tyrosine kinase receptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelial cell growth factor receptors, VEGFR-1, -2 and -3, originally named Fltl (Fms-like tyrosine ...
J, Taipale, T, Makinen, E, Arighi, E, Kukk, M, Karkkainen, K, Alitalo   +5 more
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Vascular endothelial growth factor (VEGF) and its receptors

The FASEB Journal, 1999
ABSTRACT Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a single VEGF gene. These isoforms differ in their molecular mass and in biological properties such as their ability to bind to ...
G, Neufeld, T, Cohen, S, Gengrinovitch, Z, Poltorak   +3 more
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Signal transduction by vascular endothelial growth factor receptors

Biochemical Journal, 2011
VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors.
Sina, Koch, Sònia, Tugues, Xiujuan, Li, Laura, Gualandi, Lena, Claesson-Welsh   +4 more
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Inhibitors of the vascular endothelial growth factor receptor

Hematology/Oncology Clinics of North America, 2002
The inhibitors of VEGF-mediated signaling continue to wind their way through extensive preclinical and clinical development paths. Whereas the first phase III trial did not meet its endpoints, one hopes that the others will. As we learn more about the VEGF pathways in the laboratory and the clinic, we can interpret with greater certainty what role ...
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