Results 81 to 90 of about 365,143 (361)

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors [PDF]

The Journal of Cell Biology, 2007
Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and ...
Ball, Stephen G., Shuttleworth, C. Adrian, Kielty, Cay M.   +2 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Effect of Vascular Endothelial Growth Factor Antagonist Peptide (VGB4) on Breast Tumor Growth Suppression in Vivo

Armaghane Danesh Bimonthly Journal, 2019
Background & aim: The vascular endothelial growth factor of the tumor, which binds to its receptors at the level of endothelial cells, plays an important role in vascular permeability and tumor angiogenesis.
M Farzaneh Behelgardi, S Zahri, F Mashayekhi, SM Asghari   +3 more
doaj  

Monitoring Dual VEGF Inhibition in Human Pancreatic Tumor Xenografts With Dynamic Contrast-Enhanced Ultrasound

Technology in Cancer Research & Treatment, 2020
Background: Association of drugs acting against different antiangiogenic mechanisms may increase therapeutic effect and reduce resistance. Noninvasive monitoring of changes in the antiangiogenic response of individual tumors could guide selection and ...
Michele Lamuraglia MD, PhD, Guillaume Barrois PhD, Delphine Le Guillou-Buffello PhD, Mathieu Santin PhD, Anne Kerbol MD, Eva Comperat MD, Alain Coron PhD, Olivier Lucidarme MD, PhD, S. Lori Bridal PhD   +8 more
doaj   +1 more source

LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

Cell Death and Disease, 2021
Transforming growth factor beta (TGFβ) signalling regulates extracellular matrix accumulation known to be essential for the pathogenesis of renal fibrosis; latent transforming growth factor beta binding protein 4 (LTBP4) is an important regulator of TGFβ
Chi-Ting Su, Tzu-Ming Jao, Zsolt Urban, Yue-Jhu Huang, Daniel H. W. See, Yao-Chou Tsai, Wei-Chou Lin, Jenq-Wen Huang   +7 more
doaj   +1 more source

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]

, 2012
Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
A. Balter, A. F. M. Marée, A. F. M. Marée, A. Fiorio Pla, A. Fiorio Pla, A. Fiorio Pla, A. Hunding, A. L. Bauer, A. M. Patton, A. Mottola, A. Tosin, A. W. Mahoney, B. Alberts, B. Nilius, C. C. Fink, C. D. Nobes, C. J. Drake, C. R. Kahl, C. Tomatis, D. Ambrosi, D. E. Clapham, D. Hong, D. Lovisolo, D. Wang, E. C. Kohn, E. C. Kohn, E. D. Perryn, E. L. Watson, F. Bussolino, F. Graner, F. Mac Gabhann, F. Moccia, G. Barbiero, G. Serini, H. Gerhardt, H. Kimura, H.-Y. Kwan, I. Fleming, J. A. Glazier, J. A. Glazier, J. Bennett, J. Howard, J. Klingauf, J. M. Haugh, J. R. Lancaster Jr., J. S. Pollock, J. Sneyd, J. Sneyd, K. S. Bauer, L. A. Blatter, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Munaron, L. Santella, L. V. Hryshko, M. A. Albrecht, M. D. Bootman, M. J. Berridge, M. J. Berridge, M. J. Berridge, M. J. Berridge, M. Kraus, M. S. Jafri, M. S. Steinberg, M. S. Steinberg, M. Scianna, M. Scianna, Marco Scianna, N. J. Poplawski, N. J. Savill, N. Metropolis, N. Wang, P. A. Valant, P. Bayley, P. Carmeliet, P. Carmeliet, P. Pacher, R. E. Dolmetsch, R. M. H. Merks, R. M. H. Merks, R. M. H. Merks, R. M. H. Merks, R. Meili, R. Rizzuto, S. Etienne-Manneville, S. Feske, S. Funamoto, S. Huang, S. Lin, S. M. Rafelski, S. Mittara, S. P. Khanapure, S. Wang, T. D. Pollard, T. Walther, W. Coatesworth, Y. Goto, Y. Takai   +102 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Role of Angiogenesis in Human Non-Hodgkin Lymphomas

Neoplasia: An International Journal for Oncology Research, 2013
The role of angiogenesis in the growth of lymphomas and survival of patients with leukemias and other hematological malignancies has become evident since 1994. Angiogenic factors, such as vascular endothelial growth factor and its receptors together with
Domenico Ribatti, Beatrice Nico, Girolamo Ranieri, Giorgina Specchia, Angelo Vacca   +4 more
doaj   +1 more source