Results 21 to 30 of about 364,472 (353)

VEGFR2 trafficking, signaling and proteolysis is regulated by the ubiquitin isopeptidase USP8 [PDF]

, 2016
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular function. VEGF-A binding to vascular endothelial growth factor receptor 2 (VEGFR2) stimulates endothelial signal transduction and regulates multiple cellular responses ...
Adhikari, Bruns, Bruns, Clague, Clague, Ewan, Fearnley, Gao, Horowitz, Howell, Hurley, Jopling, Jopling, Kato, Koch, Koch, Lanahan, MacDonald, McCullough, Meijer, Melker, Mizuno, Mizuno, Olsson, Pickart, Row, Sawamiphak, Shibuya, Tanaka, Wing, Zhang   +30 more
core   +1 more source

The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association

Journal of Pharmacological Sciences, 2006
M475271, 4-quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl) methoxy]-(9Cl), is a new anilinoquinazoline derivative that displays selective inhibition of Src kinase activity and tumor growth in vivo. Vascular endothelial
Nermin Ali, Masanori Yoshizumi, Seiji Yano, Saburo Sone, Hideki Ohnishi, Keisuke Ishizawa, Yasuhisa Kanematsu, Koichiro Tsuchiya, Toshiaki Tamaki   +8 more
doaj   +1 more source

Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions – A review

Journal of Oral Biology and Craniofacial Research, 2016
Angiogenesis is considered to be an important biological process in disease progression and tumorigenesis. Among the various factors associated with angiogenesis, vascular endothelial growth factor (VEGF) is a leading candidate.
Bhavana Gupta, Shaleen Chandra, Vineet Raj, Vivek Gupta   +3 more
doaj   +1 more source

The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization [PDF]

, 2011
Angiogenesis, or neovascularization, is a finely balanced process controlled by pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a major pro-angiogenic factor, whereas pigment epithelial-derived factor (PEDF) is the most ...
Crawford, Ross, Fan, Wei, Xiao, Yin
core   +2 more sources

Expression levels of vascular endothelial growth factors A and C in patients with peptic ulcers and gastric cancer [PDF]

, 2014
Purpose: Vascular endothelial growth factor (VEGF) is one of the most important growth factors for metastatic tumors. To clarify the role of VEGF-A and C in patients with peptic ulcer disease (PUD) or gastric cancer (GC), we evaluated the expression ...
Abbasi, A., Ajami, A., Ajami, M., Farazmandfar, T., Hafezi, N., Hosseini, V., Mohammadian, R., Sankian, M., Taghizadeh, S., Tehrani, M.   +9 more
core   +2 more sources

The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2008
Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory diseases and cancers.
Edward Htun van der Horst, Brendon T. Frank, Lawrence Chinn, Angela Coxon, Shyun Li, Fanny Polesso, Anthony Slavin, Astrid Ruefli-Brasse, Holger Wesche   +8 more
doaj   +1 more source

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]

, 2018
Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam, Failla, Cristina M., Morea, Veronica   +2 more
core   +2 more sources

VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy- Terminal NRP1 Fragments That Regulate Angiogenic Signaling [PDF]

, 2018
OBJECTIVE: NRP1(neuropilin-1) acts as a coreceptor for VEGF (vascular endothelial growth factor) with an essential role in angiogenesis. Recent findings suggest that posttranslational proteolytic cleavage of VEGF receptors may be an important mechanism
Evans, I M, Field, L, Jones, T, Mahmoud, M, Mehta, V, Pellet-Many, C, Yamaji, M, Zachary, I   +7 more
core   +3 more sources

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses [PDF]

, 2016
A single extracellular stimulus can promote diverse behaviors among isogenic cells by differentially regulated signaling networks. We examined Ca2+ signaling in response to VEGF (vascular endothelial growth factor), a growth factor that can stimulate ...
Chou, Wesley H., Lee, Sung Hoon, Levchenko, Andre, Noren, David P., Popel, Aleksander S., Qutub, Amina A., Wagner, Daniel S., Warmflash, Aryeh   +7 more
core   +1 more source