Results 21 to 30 of about 9,874,973 (297)

The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association

Journal of Pharmacological Sciences, 2006
M475271, 4-quinazolinamine, N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl) methoxy]-(9Cl), is a new anilinoquinazoline derivative that displays selective inhibition of Src kinase activity and tumor growth in vivo. Vascular endothelial
Nermin Ali, Masanori Yoshizumi, Seiji Yano, Saburo Sone, Hideki Ohnishi, Keisuke Ishizawa, Yasuhisa Kanematsu, Koichiro Tsuchiya, Toshiaki Tamaki   +8 more
doaj   +1 more source

Pro- and anti-fibrotic effects of vascular endothelial growth factor in chronic kidney diseases

Renal Failure, 2022
Renal fibrosis is the inevitable common end-point of all progressive chronic kidney diseases. The underlying mechanisms of renal fibrosis are complex, and currently there is no effective therapy against renal fibrosis.
Changxiu Miao, Xiaoyu Zhu, Xuejiao Wei, Mengtuan Long, Lili Jiang, Chenhao Li, Die Jin, Yujun Du   +7 more
doaj   +1 more source

Mechanisms of vascular morphogenesis and stabilization by VEGF dose [PDF]

, 2014
VEGF is the master regulator of angiogenesis and the most investigated factor in therapeutic angiogenesis approaches to induce the growth of new vessels that could restore oxygen and nutrients supply in tissues affected by ischemia.
Groppa, Elena
core   +1 more source

Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions – A review

Journal of Oral Biology and Craniofacial Research, 2016
Angiogenesis is considered to be an important biological process in disease progression and tumorigenesis. Among the various factors associated with angiogenesis, vascular endothelial growth factor (VEGF) is a leading candidate.
Bhavana Gupta, Shaleen Chandra, Vineet Raj, Vivek Gupta   +3 more
doaj   +1 more source

Clinical significance of VEGF-A, -C and -D expression in esophageal malignancies [PDF]

, 2005
Vascular endothelial growth factors ( VEGF)- A, - C and - D are members of the proangiogenic VEGF family of glycoproteins. VEGF-A is known to be the most important angiogenic factor under physiological and pathological conditions, while VEGF-C and VEGF-D
Jauch, Karl-Walter, Kleespies, A., Bruns, Christiane J.   +2 more
core   +1 more source

Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF.

PLoS ONE, 2012
Hemangiomas are tumors formed by hyper-proliferation of vascular endothelial cells. This is caused by elevated vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2).
Damian Medici, Bjorn R Olsen
doaj   +1 more source

Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. [PDF]

, 2008
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension ...
Muttukrishna Shanthi, Muttukrishna, S, Khalil Asma, Khalil, A, Jauniaux, E, Harrington, K, Jauniaux Eric, Kevin Harrington, Harrington Kevin, Shanthi Muttukrishna, Asma Khalil, Eric Jauniaux   +11 more
core   +2 more sources

The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2008
Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory diseases and cancers.
Edward Htun van der Horst, Brendon T. Frank, Lawrence Chinn, Angela Coxon, Shyun Li, Fanny Polesso, Anthony Slavin, Astrid Ruefli-Brasse, Holger Wesche   +8 more
doaj   +1 more source

Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition

Nature Communications, 2017
Soluble vascular endothelial growth factor (VEGF) enhances vascular engraftment of transplanted cells but the efficacy is low. Here, the authors show that VEGF-immobilized microparticles prolong survival of endothelial progenitors in vitro and in vivo by
Sezin Aday, Janet Zoldan, Marie Besnier, Laura Carreto, Jaimy Saif, Rui Fernandes, Tiago Santos, Liliana Bernardino, Robert Langer, Costanza Emanueli, Lino Ferreira   +10 more
doaj   +1 more source

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source