Results 41 to 50 of about 364,472 (353)

Porcine bone scaffolds adsorb growth factors secreted by MSCs and improve bone tissue repair [PDF]

, 2017
An ideal tissue-engineered bone graft should have both excellent pro-osteogenesis and pro-angiogenesis properties to rapidly realize the bone regeneration in vivo . To meet this goal, in this work a porcine bone scaffold was successfully used as a Trojan
Bressan, Eriberto, Ferroni, Letizia, Gardin, Chiara, Mijiritsky, Eitan, Piattelli, Adriano, Zanette, Gastone, Zavan, Barbara   +6 more
core   +2 more sources

Encapsulated VEGF121-PLA microparticles promote angiogenesis in human endometrium stromal cells

Journal of Genetic Engineering and Biotechnology, 2021
Background In this study, Vascular Endothelial Growth Factor 121 expressed abundantly in endometrial stromal cells is encapsulated with poly-l-lactide and characterized the properties for endometrial angiogenesis.
Sunil Abraham, Geetha Sanjay, Noushin Abdul Majiyd, Amutha Chinnaiah   +3 more
doaj   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

Gremlin is a novel agonist of the major pro-angiogenic receptor VEGFR2 [PDF]

, 2010
The bone morphogenic protein antagonist gremlin is expressed during embryonic development and under different pathologic conditions, including cancer. Gremlin is a proangiogenic protein belonging to the cystine-knot superfamily that includes transforming
Ballmer-Hofer K, Leali D, Mitola S, Moroni E, Presta M., Ravelli C, Salvi V, Zammataro L   +7 more
core   +1 more source

The splice variants of vascular endothelial growth factor (VEGF) and their receptors [PDF]

Journal of Cell Science, 2001
ABSTRACT Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role in both angiogenesis and vasculogenesis.
C J, Robinson, S E, Stringer
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration

Biology Open, 2015
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist but their physiological significance is unclear.
Gareth W. Fearnley, Alexander F. Bruns, Stephen B. Wheatcroft, Sreenivasan Ponnambalam   +3 more
doaj   +1 more source

Inhibitory mechanism of vascular endothelial growth factor (VEGF) by bucillamine [PDF]

British Journal of Pharmacology, 2002
Vascular endothelial growth factor (VEGF) plays an important role in the neovascularization of ischaemic retinal diseases such as proliferative diabetic retinopathy. We determined that bucillamine, an anti‐rheumatic drug, inhibits the VEGF production induced by hypoxia in bovine retinal microcapillary endothelial cells (BREC).
Shinji, Koyama, Hitoshi, Takagi, Atsushi, Otani, Hideyasu, Oh, Kazuo, Nishimura, Yoshihito, Honda   +5 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]

, 2013
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Plate, Karl H., Schneider, Fabian T., Wittko-Schneider, Ina M.   +2 more
core   +1 more source