Results 41 to 50 of about 12,742,672 (289)

The effect of endurance resistance exercise combined with L­citrulline malate supplement on FGF, VEGF, and fatigue among young bodybuilders [PDF]

فصلنامه ابن سینا, 2019
Background: Citrulline malate is a non-essential alpha-amino acid supplement resulting from arginine oxidation and may cause changes in the immunity, cardiovascular, and angiogenic mechanisms. It also reduces the rating of fatigue perception. The purpose
farah nameni, Mohammad Saeid Naeini Mohammadi   +1 more
doaj  

How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis? [PDF]

Anais Brasileiros de Dermatologia, 2017
: Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis.
Aline Lopes Bressan, Daniele Pereira, Paula Mota Medeiros, Sueli Carneiro, Luna Azulay-Abulafia   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Vascular function and cardiovascular risk factors in women with severe flushing [PDF]

, 2010
Background: Seventy per cent of postmenopausal women suffer from hot flushes causing significant morbidity in 25%. Oestrogen replacement provides symptom relief, but its use has declined following safety issues and there is, as yet, no good alternative ...
J. Sassarini, H. Fox, M. A. Lumsden, Fox, H., Sassarini, J., Ferrell, W., N. Sattar, Sattar, N., W. Ferrell, Lumsden, M.A.   +9 more
core   +1 more source

Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis

Health Technology Assessment
Background Diabetic retinopathy is a major cause of sight loss in people with diabetes, with a high risk of macular oedema, vitreous haemorrhage or other complications.
Mark Simmonds, Matthew Walton, Rob Hodgson, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John Lawrenson, Tunde Peto, David Steel   +12 more
doaj   +1 more source

Immunohistochemical expression of vascular endothelial growth factor in orofacial lesions – A review

Journal of Oral Biology and Craniofacial Research, 2016
Angiogenesis is considered to be an important biological process in disease progression and tumorigenesis. Among the various factors associated with angiogenesis, vascular endothelial growth factor (VEGF) is a leading candidate.
Bhavana Gupta, Shaleen Chandra, Vineet Raj, Vivek Gupta   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi, Nicole Ziegler, Fruttiger, Marcus, Rosario Heck, Sascha Seidel, Sonja Thom, Taketo, Makoto Mark, Kavi Devraj, Seidel, Sascha, Karl H. Plate, Liebner, Stefan, Reis, Marco, Bockamp, Ernesto, Heck, Rosario, Ernesto Bockamp, Marco Reis, Cathrin J. Czupalla, Makoto M. Taketo, Thom, Sonja, Zinke, Jenny, Plate, Karl, Macas, Jadranka, Jenny Zinke, Czupalla, Cathrin Jacqueline, Jadranka Macas, Stefan Liebner, Stefanie Dimmeler, Dimmeler, Stefanie, Ziegler, Nicole, Marcus Fruttiger   +29 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature [PDF]

, 2010
Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet vascularized retinal astrocytes, but also by retinal ...
Michael B. Powner, Powner, MB, Scott, A., Clarkin, C., Gandhi, P, Scott, Andrew, David H Gutmann, Randall S Johnson, Fruttiger, Marcus, Gutmann, DH, Johnson, RS, David H. Gutmann, Gutmann David H., Gutmann, David H., Powner Michael B., Gandhi, P., Scott Andrew, Clarkin Claire, Ferrara, N., Gandhi Pranita, Napoleone Ferrara, Johnson Randall S., Clarkin, Claire, Scott, A, Pranita Gandhi, Ferrara, Napoleone, Michael B Powner, Fruttiger Marcus, Gandhi, Pranita, Powner, Michael B., Ferrara Napoleone, Andrew Scott, Powner, M. B., Connon, Che John, Ferrara, N, Claire Clarkin, Clarkin, C, Fruttiger, M., Johnson, R.S., Gutmann, D.H., Fruttiger, M, Randall S. Johnson, Johnson, Randall S., Marcus Fruttiger   +43 more
core   +3 more sources