Results 81 to 90 of about 1,402,658 (304)

PHARMACOGENOMICS OF PROSTAGLANDIN AND LEUKOTRIENE RECEPTORS

Frontiers in Pharmacology, 2016
Individual genetic background together with environmental effects are thought to be behind many human complex diseases. A number of genetic variants, mainly single nucleotide polymorphisms (SNPs), have been shown to be associated with various ...
José Antonio Cornejo-García, José Antonio Cornejo-García, James Richard Perkins, Raquel Jurado-Escobar, Elena García-Martín, José A G Agúndez, Enrique Viguera, Natalia Pérez-Sánchez, Natalia Blanca-López   +8 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Mesenchymal Stem Cells Recruited by Active TGFβ Contribute to Osteogenic Vascular Calcification [PDF]

Stem Cells and Development, 2014
Vascular calcification is an actively regulated process that culminates in organized extracellular matrix mineral deposition by osteoblast-like cells. The origins of the osteoblastic cells involved in this process and the underlying mechanisms remain to be defined. We previously revealed that active transforming growth factor (TGFβ)
Weishan, Wang, Changjun, Li, Lijuan, Pang, Chenhui, Shi, Fengjing, Guo, Anmin, Chen, Xu, Cao, Mei, Wan   +7 more
openaire   +2 more sources

Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1. [PDF]

PLoS ONE, 2012
Fractalkine (CX3CL1, FKN) is expressed in the inflamed vascular wall and absence of FKN reduces atherogenesis. Whether FKN is expressed throughout all stages of atherosclerotic disease and whether it directly contributes to monocyte recruitment to ...
Moritz Stolla, Jaroslav Pelisek, Marie-Luise von Brühl, Andreas Schäfer, Verena Barocke, Peter Heider, Michael Lorenz, Anca Tirniceriu, Alexander Steinhart, Johann Bauersachs, Paul F Bray, Steffen Massberg, Christian Schulz   +12 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Global impact of the first coronavirus disease 2019 (COVID-19) pandemic wave on vascular services [PDF]

, 2020
This online structured survey has demonstrated the global impact of the COVID-19 pandemic on vascular services. The majority of centres have documented marked reductions in operating and services provided to vascular patients.
Sapienza, P, Mingoli, A, The Vascular and Endovascular Research Network (VERN) COVER study collaborative, Lapolla,P   +3 more
core   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Endothelial SMAD1/5 signaling couples angiogenesis to osteogenesis in juvenile bone

Communications Biology
Skeletal development depends on coordinated angiogenesis and osteogenesis. Bone morphogenetic proteins direct bone formation in part by activating SMAD1/5 signaling in osteoblasts. However, the role of SMAD1/5 in skeletal endothelium is unknown. Here, we
Annemarie Lang, Andreas Benn, Joseph M. Collins, Angelique Wolter, Tim Balcaen, Greet Kerckhofs, An Zwijsen, Joel D. Boerckel   +7 more
doaj   +1 more source

State of Ohio ... the employer of choice

, 2004
[Rev.].; Title from PDF cover (viewed Jan. 14, 2004).; "Hrd/rev8.30.04"--P. [4] of cover.; Harvested from the web on 1/14/05[Rev.]
Ohio. Centralized Recruitment Office
core