Results 61 to 70 of about 1,402,658 (304)
Molecular pathways of Notch signaling in vascular smooth muscle cells
Frontiers in Physiology, 2012 Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and ...
Joshua M. Boucher +3 more
doaj +1 more source
Vascular surveillance by haptotactic blood platelets in inflammation and infection
Nature Communications, 2020 Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear.
Leo Nicolai +29 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Downstream Regulation of Chemokine Receptor Signalling: Implications for Atherosclerosis
Mediators of Inflammation, 2013 Heterotrimeric G-protein-coupled receptors (GPCRs) are key mediators of intracellular signalling, control numerous physiological processes, and are one of the largest class of proteins to be pharmacologically targeted.
Jyoti Patel +2 more
doaj +1 more source
Cell Reports, 2023 Summary: Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammation ...
Anna L. Gray +23 more
doaj +1 more source
Functional diversity of extracellular matrix components during vessel migration, endothelial sprouting and blood vessel stabilization [PDF]
, 2009 The formation of mature blood vessels requires recruitment of mural cells (MC) and generation of an extracellular matrix in order to stabilize and support the nascent vessel.
Stenzel, D.
core
Role of nutritional indices in predicting outcomes of vascular surgery [PDF]
, 2019 Background: Malnutrition is frequent among vascular surgery patients, given their age, chronic comorbidities, and poor functional status, and it is believed to increase their operative risk.
Rabeh, Wissam +5 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Cell based therapeutic approach in vascular surgery: application and review
Open Medicine, 2017 Multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside.
Rocca Aldo +10 more
doaj +1 more source
eLife, 2023 The inner layer of blood vessels consists of endothelial cells, which form the physical barrier between blood and tissue. This vascular barrier is tightly regulated and is defined by cell-cell contacts through adherens and tight junctions. To investigate
Eike K Mahlandt +5 more
doaj +1 more source