Results 41 to 50 of about 1,402,658 (304)

Microkinetics of leukocyte recruitment imaged in vascular mimetics

The FASEB Journal, 2006
A photolithography fabricated microfluidic system is presented that directs small volumes of leukocytes (~ 1 μl) in a controlled chemical environment under physiological shear stress over a vascular mimetic surface that can be imaged on an inverted microscope.
Ulrich Y Schaff, Mengqiu Xing, Kathleen K Lin, Scott I Simon   +3 more
openaire   +1 more source

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

Nature Communications, 2018
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders.
Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G. Arroyo   +14 more
doaj   +1 more source

Myeloid IκBα deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques. [PDF]

, 2011
Activation of the transcription factor NF-κB appears to be involved in different stages of atherogenesis. In this paper we investigate the role of NF-κB inhibitor IκBα in atherosclerosis.
Menno P J de Winther, Hofker Marten H., Hofker, Marten H., Rupec Rudolf A., Curfs Danielle M. J., Woezik, J.H.G. (Johannes H.) van, Hoeksema, Marten A., Goossens, P. (Pieter), Rudolf A Rupec, Hoeksema Marten A., Leenen, Pieter J. M., Leenen, P.J.M. (Pieter), Winther, M.P.J. (Menno P.) de, Marion J. J. Gijbels, Leenen Pieter J. M., Hoeksema, M.A. (Marten), Danielle M J Curfs, Pieter J M Leenen, Marten A. Hoeksema, Gijbels, Marion J. J., Vergouwe, Monique N., Gijbels, M. (Marion), Johannes H. G. van Woezik, Rupec, R.A. (Rudolf), Xanthouleas, Sofia, de Winther, Menno P. J., Gijbels Marion J. J., Monique N. Vergouwe, Xanthoulea Sofia, Goossens, Pieter, Curfs, Danielle M. J., Johannes H G van Woezik, Marten H. Hofker, van Woezik, Johannes H. G., Marion J J Gijbels, Xanthoulea, Sofia, Vergouwe, Y. (Yvonne), Xanthoulea, S. (Sofia), van Woezik Johannes H. G., Sofia Xanthoulea, Goossens Pieter, Vergouwe Monique N., Rupec, Rudolf A., Hofker, M.A. (Marten), Curfs, D.M.J. (Danielle M.), Marten A Hoeksema, Marten H Hofker, Pieter J. M. Leenen, Menno P. J. de Winther, Danielle M. J. Curfs, de Winther Menno P. J., Rudolf A. Rupec, Pieter Goossens, Monique N Vergouwe, Hofker, MH, Curfs, DMJ, Rupec, RA, van Woezik, JHG, Vergouwe, MN, Gijbels, MJJ, de Winther, MPJ, Goossens, P, Xanthoulea, S, Hoeksema, MA, Leenen, Pieter   +64 more
core   +4 more sources

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles [PDF]

Journal of Clinical Investigation, 2016
Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that are implicated in atherosclerotic plaque rupture; however, the mechanisms that regulate formation of calcifying extracellular vesicles remain obscure.
Goettsch, Claudia, Hutscheson, JD, Aikawa, M, Iwata, H, Pham, T, Nykjær, Anders; id_orcid 0000-0001-6422-6736, Kjølby, Mads Fuglsang; id_orcid 0000-0002-1043-6137, Rogers, Michel, Michel, T, Shibasaki, M, Hagita, S, Kramann, Raphael, Rader, Daniel J, Libby, Peter, Singh, SA, Aikawa, Elena   +15 more
openaire   +2 more sources

Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase

Journal of Lipid Research, 2005
Previous studies have shown apolipoprotein E (apoE) recruitment to medial layers of carotid arteries after vascular injury in vivo and apoE activation of inducible nitric oxide synthase (iNOS) in smooth muscle cells in vitro.
Zachary W.Q. Moore, David Y. Hui
doaj   +1 more source

Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle [PDF]

Open Biology, 2018
Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α1-adrenoceptors. Here, we show that ACKR3 also regulates
Lauren J. Albee, Heather M. LaPorte, Xianlong Gao, Jonathan M. Eby, You-Hong Cheng, Amanda M. Nevins, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak   +8 more
doaj   +1 more source

Vascular co-option in resistance to anti-angiogenic therapy

Frontiers in Oncology, 2023
Three different mechanisms of neovascularization have been described in tumor growth, including sprouting angiogenesis, intussusceptive microvascular growth and glomeruloid vascular proliferation.
Domenico Ribatti, Tiziana Annese, Tiziana Annese, Roberto Tamma   +3 more
doaj   +1 more source

Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection

Frontiers in Cell and Developmental Biology, 2020
Upon vascular injury, tissue damage, ischemia, or microbial infection, intracellular material such as nucleic acids and histones is liberated and comes into contact with the vessel wall and circulating blood cells.
Klaus T. Preissner, Klaus T. Preissner, Silvia Fischer, Elisabeth Deindl, Elisabeth Deindl   +4 more
doaj   +1 more source

Platelet PI3Kγ Contributes to Carotid Intima-Media Thickening under Severely Reduced Flow Conditions. [PDF]

PLoS ONE, 2015
Studies have begun to focus on the emerging function of platelets as immune and inflammatory cells that initiate and accelerate vascular inflammation.
Cuiping Wang, Rong Jin, Anil Nanda, Jinchuan Yan, Guohong Li   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source