Results 31 to 40 of about 318,912 (261)

Microkinetics of leukocyte recruitment imaged in vascular mimetics

The FASEB Journal, 2006
A photolithography fabricated microfluidic system is presented that directs small volumes of leukocytes (~ 1 μl) in a controlled chemical environment under physiological shear stress over a vascular mimetic surface that can be imaged on an inverted microscope.
Ulrich Y Schaff, Mengqiu Xing, Kathleen K Lin, Scott I Simon   +3 more
openaire   +1 more source

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

Nature Communications, 2018
Matrix metalloproteinases (MMP) are involved in vascular remodeling associated with plaque progression. Little is known about their immune regulatory role in vascular disorders.
Cristina Clemente, Cristina Rius, Laura Alonso-Herranz, Mara Martín-Alonso, Ángela Pollán, Emilio Camafeita, Fernando Martínez, Rubén A. Mota, Vanessa Núñez, Cristina Rodríguez, Motoharu Seiki, José Martínez-González, Vicente Andrés, Mercedes Ricote, Alicia G. Arroyo   +14 more
doaj   +1 more source

Vascular co-option in resistance to anti-angiogenic therapy

Frontiers in Oncology, 2023
Three different mechanisms of neovascularization have been described in tumor growth, including sprouting angiogenesis, intussusceptive microvascular growth and glomeruloid vascular proliferation.
Domenico Ribatti, Tiziana Annese, Tiziana Annese, Roberto Tamma   +3 more
doaj   +1 more source

Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase

Journal of Lipid Research, 2005
Previous studies have shown apolipoprotein E (apoE) recruitment to medial layers of carotid arteries after vascular injury in vivo and apoE activation of inducible nitric oxide synthase (iNOS) in smooth muscle cells in vitro.
Zachary W.Q. Moore, David Y. Hui
doaj   +1 more source

Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle [PDF]

Open Biology, 2018
Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α1-adrenoceptors. Here, we show that ACKR3 also regulates
Lauren J. Albee, Heather M. LaPorte, Xianlong Gao, Jonathan M. Eby, You-Hong Cheng, Amanda M. Nevins, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak   +8 more
doaj   +1 more source

Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and Infection

Frontiers in Cell and Developmental Biology, 2020
Upon vascular injury, tissue damage, ischemia, or microbial infection, intracellular material such as nucleic acids and histones is liberated and comes into contact with the vessel wall and circulating blood cells.
Klaus T. Preissner, Klaus T. Preissner, Silvia Fischer, Elisabeth Deindl, Elisabeth Deindl   +4 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Platelet PI3Kγ Contributes to Carotid Intima-Media Thickening under Severely Reduced Flow Conditions. [PDF]

PLoS ONE, 2015
Studies have begun to focus on the emerging function of platelets as immune and inflammatory cells that initiate and accelerate vascular inflammation.
Cuiping Wang, Rong Jin, Anil Nanda, Jinchuan Yan, Guohong Li   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth [PDF]

The Journal of Pathology, 2018
AbstractAggressive tumor cells can adopt an endothelial cell‐like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the
Thijssen, Victor L.JL., Paulis, Yvette W.J., Nowak-Sliwinska, Patrycja, Deumelandt, Katrin L., Hosaka, Kayoko, Soetekouw, Patricia M.MB., Cimpean, Anca M., Raica, Marius, Pauwels, Patrick, van den Oord, Joost J., Tjan-Heijnen, Vivianne C.G., Hendrix, Mary J., Heldin, Carl-Henrik, Cao, Yihai, Griffioen, Arjan W.   +14 more
openaire   +9 more sources