Results 51 to 60 of about 1,402,658 (304)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth [PDF]

The Journal of Pathology, 2018
AbstractAggressive tumor cells can adopt an endothelial cell‐like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the
Thijssen, Victor L.JL., Paulis, Yvette W.J., Nowak-Sliwinska, Patrycja, Deumelandt, Katrin L., Hosaka, Kayoko, Soetekouw, Patricia M.MB., Cimpean, Anca M., Raica, Marius, Pauwels, Patrick, van den Oord, Joost J., Tjan-Heijnen, Vivianne C.G., Hendrix, Mary J., Heldin, Carl-Henrik, Cao, Yihai, Griffioen, Arjan W.   +14 more
openaire   +9 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Pulmonary capillary surface area in supine exercising humans: demonstration of vascular recruitment [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2019
In exercising humans, cardiac output (CO) increases, with minor increases in pulmonary artery pressure (PAP). It is unknown if the CO is accommodated via distention of already perfused capillaries or via recruitment of nonconcomitantly perfused pulmonary capillaries. Ten subjects (9 female) performed symptom-limited exercise. Six had resting mean PAP (
David Langleben, Stylianos E. Orfanos, Michele Giovinazzo, Robert D. Schlesinger, Robert Naeije, Benjamin D. Fox, Ali O. Abualsaud, Fay Blenkhorn, Lawrence G. Rudski, John D. Catravas   +9 more
openaire   +4 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Diretrizes sobre trombose venosa profunda da Sociedade Brasileira de Angiologia e Cirurgia Vascular

Deep vein thrombosis is one of the main causes of inpatient and outpatient morbidity, both in medical and surgical patients, significantly impacting mortality statistics and requiring prompt diagnosis so that treatment can be initiated immediately.
Ribeiro, Alcides José Araújo, Burihan, Marcelo Calil, Casella, Ivan Benaduce, Sobreira, Marcone Lima [UNESP], Matielo, Marcelo Fernando, de Araujo, Walter Junior Boin, de Oliveira, Julio Cesar Peclat, Paschoa, Adilson Ferraz, Marques, Marcos Áreas, Soares, Rafael de Athayde, Joviliano, Edwaldo Edner   +10 more
core   +2 more sources

Vascular Targeted Agents for the Treatment of Angiosarcoma [PDF]

, 2013
Background: Angiogenesis is the process of new blood vessel formation, and is regulated by angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiosarcomas are rare, aggressive vascular tumours.
P J Woll (16226153), R J Young (13425891), C A Staton (16226156), Malcolm Reed (4465876), Young, Robin, N J Brown (13424178)   +5 more
core  

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga, Nina Berberich, Peter Bihari, Stefan Zahler, Rehberg, Markus, Fritz Krombach, Krombach, Fritz, Max Lerchenberger, Lerchenberger, Max, Berberich, Nina, Reichel, Christoph A., Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Zahler, Stefan, Khandoga, Alexander G.   +15 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cognitive profiles of vascular and neurodegenerative MCI [PDF]

, 2008
The objective of the thesis was to investigate the cognitive profiles of different types of mild cognitive impairment (MCI) and follow their course over time.
Nordlund, Arto
core   +1 more source