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Vascular smooth muscle contraction in hypertension [PDF]
Cardiovascular Research, 2018 Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to ...
Touyz, Rhian M. +6 more
semanticscholar +8 more sources
Vascular Smooth Muscle Updated [PDF]
Circulation Research, 1973 • This brief review of the rapidly developing research on vascular smooth muscle presents the state of the art as I see it from within my own frame of reference. For a more objective, detailed insight into the workings of vascular smooth muscle, several substantial reviews and compendiums may be read (1-7).
David F. Bohr
openalex +4 more sources
Vascular Smooth Muscle Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
M. Majesky
openaire +4 more sources
Vascular smooth muscle cells in atherosclerosis [PDF]
Nature Reviews Cardiology, 2019 Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the 'response to injury' and 'vulnerable plaque' hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and ...
Martin R. Bennett +6 more
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Guidance Molecules in Vascular Smooth Muscle [PDF]
Frontiers in Physiology, 2018 Several highly conserved families of guidance molecules, including ephrins, Semaphorins, Netrins, and Slits, play conserved and distinct roles in tissue remodeling during tissue patterning and disease pathogenesis.
Alexandra Christine Finney +3 more
doaj +4 more sources
Long non-coding RNAs: Modulators of phenotypic transformation in vascular smooth muscle cells
Frontiers in Cardiovascular Medicine, 2022 Long non-coding RNA (lncRNAs) are longer than 200 nucleotides and cannot encode proteins but can regulate the expression of genes through epigenetic, transcriptional, and post-transcriptional modifications.
Bing-Han Lu +16 more
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How vascular smooth muscle cell phenotype switching contributes to vascular disease
Cell Communication and Signaling, 2022 Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a ...
Genmao Cao +5 more
semanticscholar +1 more source
Vascular smooth muscle cells in atherosclerosis:Time for a reassessment.
Cardiovascular Research, 2021 Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding lesions, but also forming a protective fibrous cap rich in extracellular ...
M. Grootaert, M. Bennett
semanticscholar +1 more source
Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.
Circulation, 2021 Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain ...
J. Miano, E. Fisher, M. Majesky
semanticscholar +1 more source
Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
doaj +1 more source