Results 11 to 20 of about 487,889 (261)

Human Vascular Smooth Muscle Function and Oxidative Stress Induced by NADPH Oxidase with the Clinical Implications

Cells, 2021
Among reactive oxygen species, superoxide mediates the critical vascular redox signaling, resulting in the regulation of the human cardiovascular system.
Kazumi Takaishi, Hiroyuki Kinoshita, Shingo Kawashima, Shinji Kawahito   +3 more
doaj   +1 more source

EPAC in Vascular Smooth Muscle Cells [PDF]

International Journal of Molecular Sciences, 2020
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Nadine Wehbe, Suzanne Awni Nasser, Yusra Al-Dhaheri, Rabah Iratni, Alessandra Bitto, Ahmed F. El-Yazbi, Adnan Badran, Firas Kobeissy, Elias Baydoun, Ali H. Eid   +9 more
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iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. [PDF]

PLoS ONE, 2012
Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown.
Lindsay E Calderon, Shu Liu, Wen Su, Zhongwen Xie, Zhenheng Guo, Wanda Eberhard, Ming C Gong   +6 more
doaj   +1 more source

Biochemical Properties of a Bushmaster Snake Venom Serine Proteinase (LV-Ka), and Its Kinin Releasing Activity Evaluated in Rat Mesenteric Arterial Rings

Journal of Pharmacological Sciences, 2004
A serine proteinase with kallikrein-like activity (LV-Ka) has been purified to homogeneity from bushmaster snake (Lachesis muta muta) venom. Physicochemical studies indicated that LV-Ka is a single chain glycoprotein with a molecular mass (Mr) of 33 kDa ...
Maria L.D. Weinberg, Liza F. Felicori, Cynthia A. Bello, Henrique P.B. Magalhães, Alvair P. Almeida, Arinos Magalhães, Eladio F. Sanchez   +6 more
doaj   +1 more source

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel, Ricardo Espinosa-Tanguma, Madeline Nieves-Cintron, Manuel F. Navedo   +3 more
doaj   +1 more source

Acute glucose influx-induced mitochondrial hyperpolarization inactivates myosin phosphatase as a novel mechanism of vascular smooth muscle contraction

Cell Death and Disease, 2021
It is well-established that long-term exposure of the vasculature to metabolic disturbances leads to abnormal vascular tone, while the physiological regulation of vascular tone upon acute metabolic challenge remains unknown.
Jie Xu, Hongyan Yang, Lu Yang, Zhen Wang, Xinghua Qin, Jiaheng Zhou, Ling Dong, Jia Li, Minsheng Zhu, Xing Zhang, Feng Gao   +10 more
doaj   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

Vascular Smooth Muscle Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully differentiated phenotype conferred by the transcriptional activity of myocardin and serum response ...
openaire   +2 more sources

Differentiation of multipotent vascular stem cells contributes to vascular diseases. [PDF]

, 2012
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases.
Chu, Julia S, Helms, Jill A, Li, Song, Liu, Bo, Tang, Zhenyu, Wang, Aijun, Yan, Zhiqiang, Yuan, Falei   +7 more
core   +1 more source

Vascular Smooth Muscle Updated [PDF]

Circulation Research, 1973
• This brief review of the rapidly developing research on vascular smooth muscle presents the state of the art as I see it from within my own frame of reference. For a more objective, detailed insight into the workings of vascular smooth muscle, several substantial reviews and compendiums may be read (1-7).
openaire   +2 more sources