Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cells in vitro
Frontiers in Physiology, 2022 Vascular smooth muscle cell plasticity plays a pivotal role in the pathophysiology of vascular diseases. Despite compelling evidence demonstrating the importance of transcription factor GATA6 in vascular smooth muscle, the functional role of GATA6 ...
Azra Alajbegovic +6 more
doaj +1 more source
Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.
Circulation, 2021 Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain ...
J. Miano, E. Fisher, M. Majesky
semanticscholar +1 more source
The role of p53 in the alternation of vascular functions
Frontiers in Pharmacology, 2022 Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system.
Gabriel Hoi-Huen Chan +7 more
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Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function. [PDF]
PLoS ONE, 2015 Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including ...
Jennifer M Kleinhenz +10 more
doaj +1 more source
Vinpocetine Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells. [PDF]
PLoS ONE, 2016 Vascular calcification is an active process of osteoblastic differentiation of vascular smooth muscle cells; however, its definite mechanism remains unknown.
Yun-Yun Ma +8 more
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Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury [PDF]
, 2014 Background The origins of neointimal smooth muscle cells that arise following vascular injury remains controversial. Studies have suggested that these cells may arise from previously differentiated medial vascular smooth muscle cells, resident stem ...
Burlak, Christopher +3 more
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Cells, 2021 Among reactive oxygen species, superoxide mediates the critical vascular redox signaling, resulting in the regulation of the human cardiovascular system.
Kazumi Takaishi +3 more
doaj +1 more source
Metabolism of vascular smooth muscle cells in vascular diseases.
American Journal of Physiology. Heart and Circulatory Physiology, 2020 Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer of arteries and are essential for arterial physiology and pathology.
Jia Shi +4 more
semanticscholar +1 more source
Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells
Frontiers in Endocrinology, 2020 The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel +3 more
doaj +1 more source
Differentiation of multipotent vascular stem cells contributes to vascular diseases. [PDF]
, 2012 It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases.
Chu, Julia S +7 more
core +1 more source