Results 101 to 110 of about 385,157 (356)

How vascular smooth muscle cell phenotype switching contributes to vascular disease

Cell Communication and Signaling, 2022
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a ...
Genmao Cao, Xuezhen Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong   +5 more
doaj   +1 more source

Notch and Vascular Smooth Muscle Cell Phenotype [PDF]

Circulation Research, 2008
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch gene regulatory network is often recapitulated in the context of phenotypic modulation of vascular smooth muscle cells (VSMC), vascular remodeling, and repair in ...
David A. Morrow, Tony E. Walshe, Colm O'Brien, Shaunta Guha, Dermot Walls, Catherine Sweeney, Yvonne A. Birney, Paul A. Cahill, Eileen M. Redmond   +8 more
openaire   +3 more sources

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

Cytoglobin Expression Is Induced in Vascular Smooth Muscle Cells Through Endothelial Cell-Derived Notch Signaling: Implications of a Protective Role in Blood Vessel Function [PDF]

, 2017
Communication between endothelial cells and smooth muscle cells is required for normal blood vessel formation and function. My research focuses on understanding the molecular signaling pathways that govern cell-cell communication and maintain vascular ...
Dammeyer, Kristen
core  

Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells [PDF]

, 2003
Akt is activated by growth factors to regulate various aspects of vascular smooth muscle cell function. Platelet-derived growth factor (PDGF) and insulin-like growth factor-1 activated Akt in vascular smooth muscle cells with a rapid reduction of total ...
Bai, Basso, Bayes-Genis, Bellas, Duan, Fingerle, Force, Gesbert, Grant, Hayashi, Hayashi, Higaki, Imai, Jawien, Kobayashi, Lee, Lin, Ogawara, Pianetti, Plas, Rui, Sata, Scheid, Sun, Zhande   +24 more
core   +1 more source

Joule‐Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures

Advanced Functional Materials, EarlyView.
Joule‐assisted nanotherapeutic urethral stent harnesses a smart, biodegradable magnesium stent to orchestrate spatiotemporal theragenerative therapy for urethral strictures. Magnetically induced Joule heating enables on‐demand drug release and bacterial ablation, while simultaneously guiding urothelial regeneration.
Yuhyun Na, Yubeen Park, Hyun Lee, Song Hee Kim, Seojoon Bang, Hyeong Seok Kang, Chan Ho Moon, Ju Yeong Gwon, Jong Hwa Seo, Min‐Ho Kang, Soo‐Hong Lee, Gi Doo Cha, Wooram Park, Heemin Kang, Jung‐Hoon Park, Hyun‐Do Jung   +15 more
wiley   +1 more source

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
By fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels, a new class of granular hydrogel scaffolds with hierarchical porosity is developed. These scaffolds have a significantly higher void fraction than their counterparts made up of nonporous microgels, enhancing cell recruitment and tissue integration. This research may
Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi   +9 more
wiley   +1 more source

A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-kB [PDF]

, 2015
Vascular calcifications bear the risk for cardiovascular complications and have a high prevalence among patients with chronic kidney disease. Central mediators of vascular calcifications are vascular smooth muscle cells (VSMC).
Freise, Christian, Kim, Ki Young, Querfeld, Uwe   +2 more
core   +1 more source

The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants

Advanced Functional Materials, EarlyView.
4D printing enables the creation of smart implants that adapt to changing conditions in the human body over time. At the core of this technology are shape‐memory thermomorphs (SMTMs). This review offers an in‐depth analysis of 4D printing with SMTMs, emphasizing the latest advancements in smart materials, stimuli, programming principles, and their ...
Aixiang Ding, Fang Tang, Eben Alsberg
wiley   +1 more source

cGMP Signaling and Vascular Smooth Muscle Cell Plasticity

Journal of Cardiovascular Development and Disease, 2018
Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This review summarizes the effects of cGMP on the growth and survival of vascular smooth muscle cells (VSMCs), which display remarkable phenotypic plasticity during the ...
Moritz Lehners, Hyazinth Dobrowinski, Susanne Feil, Robert Feil   +3 more
doaj   +1 more source