Results 41 to 50 of about 242,639 (216)

Galectin-3 Mediates Thrombin-Induced Vascular Smooth Muscle Cell Migration

Frontiers in Cardiovascular Medicine, 2021
Vascular smooth muscle cell (VSMC) migration is an important step in the progression and development of vulnerable plaques. Thrombin is involved in both physiological and pathological processes of atherosclerosis.
Lei Tian, Chun-Kai Huang, Fenghua Ding, Ruiyan Zhang   +3 more
doaj   +1 more source

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]

, 2012
We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Sessa, W.C., Chick, H.E., Kane, N.M., Baker, A.H., Thrasher, A.J., Alba, R., Fronza, R., McDonald, R.A., Delles, C., Schmidt, M., Nowrouzi, A.   +10 more
core   +1 more source

Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy

Frontiers in Physiology, 2017
There are two primary components that produce pulmonary arterial hypertension (PAH); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary ...
Melissa A. Lyle, Jonathan P. Davis, Frank V. Brozovich   +2 more
doaj   +1 more source

Biophysical induction of vascular smooth muscle cell podosomes. [PDF]

PLoS ONE, 2015
Vascular smooth muscle cell (VSMC) migration and matrix degradation occurs with intimal hyperplasia associated with atherosclerosis, vascular injury, and restenosis.
Na Young Kim, Julie C Kohn, John Huynh, Shawn P Carey, Brooke N Mason, Ageliki G Vouyouka, Cynthia A Reinhart-King   +6 more
doaj   +1 more source

Notch and Vascular Smooth Muscle Cell Phenotype [PDF]

Circulation Research, 2008
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch gene regulatory network is often recapitulated in the context of phenotypic modulation of vascular smooth muscle cells (VSMC), vascular remodeling, and repair in ...
David, Morrow, Shaunta, Guha, Catherine, Sweeney, Yvonne, Birney, Tony, Walshe, Colm, O'Brien, Dermot, Walls, Eileen M, Redmond, Paul A, Cahill   +8 more
openaire   +2 more sources

Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries.

, 2012
Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Reddy, M, Szewczyk, K, Greenwood, IA, Vasilikostas, G, Harhun, MI, Wan, A, Khong, TK, Ratnasingham, K, Moss, RF, Huggins, CL, Raje, D   +10 more
core   +1 more source

Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells [PDF]

, 2015
© 2015 Macmillan Publishers Limited. All rights reserved. microRNA-34a (miR-34a) and sirtuin 1 (SirT1) have been extensively studied in tumour biology and longevityaging, but little is known about their functional roles in smooth muscle cell (SMC ...
L A Luong, Wen, G., Q Chen, Luong, LA, Q Xiao, Zhu, J, Zhu, J., Chen, Q, Y Huang, Luong, L. A., Zhang, L., Ye, S., H Zhao, G Wen, Wang, W, L Zhang, Xu, Q., Yu, X., Wen, G, Xiao, Q, Ye, S, Huang, Y, Q Xu, Zhao, H, X Yu, Huang, Y., Xu, Q, W Wang, Chen, Q., J Zhu, Yu, X, Zhang, L, Wang, W., Xiao, Q., Zhao, H., S Ye   +35 more
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Depletion of Mitochondrial Cyclophilin D in Endothelial and Smooth Muscle Cells Attenuates Vascular Dysfunction and Hypertension

Function
Hypertension is a major risk factor of cardiovascular disease affecting nearly half of adult population. It is associated with mitochondrial dysfunction and understanding these mechanisms is important to develop new therapies.
Anna Dikalova, Mingfang Ao, Louise Lantier, Sergey Gutor, Sergey Dikalov   +4 more
doaj   +1 more source

Origin and differentiation of vascular smooth muscle cells [PDF]

The Journal of Physiology, 2015
Abstractimage Vascular smooth muscle cells (SMCs), a major structural component of the vessel wall, not only play a key role in maintaining vascular structure but also perform various functions. During embryogenesis, SMC recruitment from their progenitors is an important step in the formation of the embryonic vascular system.
Wang, Gang, Jacquet, Laureen, Karamariti, Eirini, Xu, Qingbo   +3 more
openaire   +3 more sources

Notch signaling pathway in human vascular smooth muscle cell differentiation [PDF]

, 2006
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to ...
Scheller, Agnieszka
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