Results 71 to 80 of about 385,157 (356)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Vascular Smooth Muscle Cell Proliferation in Restenosis [PDF]

Circulation: Cardiovascular Interventions, 2011
Current therapeutic approaches to restore blood flow in stenotic blood vessels involve the use of percutaneous devices and coronary bypass surgery. In all procedures that disrupt the normal integrity of the blood vessels, there is an increased incidence of vessel luminal narrowing, termed restenosis.
Steven O. Marx, Hana Totary-Jain, Andrew R. Marks   +2 more
openaire   +2 more sources

Pathogenesis of abdominal aortic aneurysms: Possible role of differential production of proteoglycans by smooth muscle cells [PDF]

, 1998
Purpose: In vivo and in vitro observations strongly suggest that marked differences exist in the phenotype, growth, and matrix-producing capabilities of distinct smooth muscle cell subpopulations.
Ghosh, Peter, Melrose, James, Whitelock, John, Xu, Qian   +3 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension

Pulmonary Circulation, 2021
Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon, Guanming Qi, Seung K. Kim, M. Elizabeth Moss, Krishna C. Penumatsa, Rod R. Warburton, Deniz Toksoz, Jamie Wilson, Nicholas S. Hill, Iris Z. Jaffe, Ioana R. Preston   +10 more
doaj   +1 more source

Endothelial dysfunction and vascular disease [PDF]

, 2009
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor (EDRF) is nitric oxide (NO).
Abeywardena, Aikawa, Ajayi, Alexopoulos, Alp, Anselm, Ardigo, Arehart, Argacha, Asano, Aubin, Aubin, Auch-Schwelk, Auch-Schwelk, Auch-Schwelk, Auch-Schwelk, August, Bachschmid, Barton, Basu, Bauersachs, Bechara, Behrendt, Belhassen, Bellamy, Bellien, Benndorf, Blanco-Rivero, Boban, Bode-Böger, Borg-Capra, Bos, Boulanger, Boulanger, Bouvet, Brandes, Briet, Bucala, Budhiraja, Bulckaen, Busse, Busse, Buzzard, Böger, Böger, Böhm, Cai, Camacho, Celermajer, Cernadas, Challah, Chambers, Chan, Chan, Chan, Charpie, Chauhan, Chen, Cheng, Chou, Chu, Cohen, Cohen, Coimbra, Cooke, Cosentino, Cosentino, Cox, Csiszar, Csiszar, Csiszar, Dantas, Dantas, Das, Davidge, Davidge, Davies, Davis, De Mey, De Mey, De Mey, De Vriese, DeLano, Dell’Agli, Derkach, Dhein, Dickson, Dimmeler, Dudzinski, Duffy, Duncan, Engler, Eringa, Eto, Feron, Ferreiro, Fichtlscherer, Filipe, Filser, Fisher, Fisslthaler, Flammer, Flavahan, Flavahan, Fleming, Fleming, Focardi, Fournet-Bourguignon, Frank, Fresquet, Furchgott, Furchgott, Furchgott, Furuhashi, Furuhashi, Félétou, Félétou, Félétou, Félétou, Félétou, Förstermann, Gamboa, Ganz, Gao, Garcia-Cohen, Ge, Ge, Gertz, Gill, Gisclard, Gluais, Gluais, Gluais, Goel, Gollasch, Graier, Grassi, Grisk, Gryglewski, Guns, Guzik, Halcox, Hambrecht, Han, Hanratty, Hansson, Hashikabe, Hattori, Heeba, Heiss, Herrmann, Heymes, Hibbert, Hirao, Hodgson, Holowatz, Hongo, Hoo, Houston, Houston, Hristovska, Husain, Hutri-Kahonen, Iellamo, Ignarro, Ignarro, Ignarro, Ijzerman, Ikeda, Indik, Inkster, Inoue, Iqbal, Ito, Iwama, Iwatani, Jankowski, Kagota, Kaiser, Kajiya, Kanani, Karagiannis, Kato, Katusic, Katusic, Katusic, Katusic, Katusic, Katz, Kaul, Kauser, Kennedy, Keung, Kim, Kim, Kirkby, Klöß, Knight, Koga, Koga, Kojda, Kubo, Kung, Kuriyama, Kuvin, Kähönen, Lamping, Landmesser, Landmesser, Landmesser, Lang, Lang, Lauer, Lavi, Lee, Lee, Lefèvre, Leikert, Lembo, Lesniewski, Leung, Levine, Levy, Li, Li, Li, Li, Li, Lida, Lin, Liu, Lockette, Looft-Wilson, Lopez-Sepulveda, Lu, Ludmer, Luz, Lyons, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Lüscher, Macarthur, Machha, Machha, Maejima, Malo, Mancini, Marletta, Matoba, Matsumoto, Mayhan, Mayhan, Meyer, Michaud, Michel, Michel, Michel, Miller, Miller, Miller, Miller, Ming, Mitchell, Miyagawa, Moat, Mombouli, Mombouli, Mombouli, Mombouli, Moncada, Monobe, Monsalve, Montalcini, Morikawa, Moritoki, Motley, Mundy, Nagata, Nakamura, Nassar, Naya, Nietlispach, Nigris, Nigris, Nigris, Norel, Numaguchi, Obrosova, Okano, Okon, Ospina, O’Rourke, Pacher, Palm, Palmer, Palmer, Palmer, Palmer, Pannirselvam, Paulis, Pearson, Pellegrini, Perticone, Pierce, Quijano, Radomski, Rakobowchuk, Rapoport, Romero, Ross, Rossi, Roves, Rubanyi, Rubanyi, Rubanyi, Rubanyi, Rubanyi, Ryoo, Ryoo, Saifeddine, Santhanam, Santos, Sarr, Sartorio, Sata, Sbarouni, Schini, Schini, Schini, Schini-Kerth, Schroeter, Schäfer, Scott, Sekikawa, Sena, Shepherd, Shi, Shi, Shi, Shi, Shi, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shimokawa, Shirahase, Silva, Skott, Smith, Soares de Moura, Sousa, Spier, Spooner, Steinberg, Stepp, Stocker, Stocker, Stockley, Stuehr, Stähli, Subramanian, Sun, Suvorava, Suwaidi, Taddei, Taddei, Taddei, Taddei, Taddei, Taddei, Taddei, Tan, Tang, Tang, Tang, Tang, Tang, Tang, Taubert, Tesfamariam, Tesfamariam, Tesfamariam, Tesfamariam, Tostes, Touyz, Touyz, Traupe, Traupe, Treasure, Trochu, Tschudi, Tschudi, Uhrenholt, Uhrenholt, Ungvari, Vallance, Vallejo, Van Guilder, Van Guilder, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Vanhoutte, Voetsch, von Schacky, Wallerath, Wang, Wang, Wassmann, Watts, Widder, Wilson, Wong, Wong, Xiang, Xiong, Xu, Xu, Yan, Yanagisawa, Yanagisawa, Yang, Yang, Yasuro, Yin, Zampetaki, Zerrouk, Zhang, Zhao, Zhong, Zhou, Zhou, Zhu, Zou, Zou, Álvarez, Álvarez   +460 more
core   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Transfer and Expression of the Interferon Gamma Gene in Human Endothelial Cells Inhibits Vascular Smooth Muscle Cell Growth in Vitro

Cell Transplantation, 1997
Intimal hyperplasia in blood vessels is primarily caused by the migration and proliferation of vascular smooth muscle cells. Excessive intimal thickening characterizes atherosclerosis as well as bypass graft and angioplasty failures.
Alison T. Stopeck M.D., Mahmood Vahedian, Stuart K. Williams   +2 more
doaj   +1 more source

Effect of Caspase Inhibitor Ac-DEVD-CHO on Apoptosis of Vascular Smooth Muscle Cells Induced by Artesunate

AIMS Bioengineering, 2014
Numerous studies have shown that the proliferation and apoptosis of vascular smooth muscle cells play a key role in restenosis. Artesunate is a triterpenoid with a peroxide structure and its antimalarial, antitumor, and antiangiogenetic activities can ...
Jingwen Zhang, Lu Wang, Huolin Chen, Tieying Yin, Yanqun Teng, Kang Zhang, Donghong Yu, Guixue Wang   +7 more
doaj   +1 more source

Fibrinogen is chemotactic for vascular smooth muscle cells

FEBS Letters, 1989
We studied the effect of fibrinogen on the migration of bovine aortic smooth muscle cells in culture, using a Neuro Probe 48‐well micro chemotaxis chamber. Fibrinogen stimulated the migration of the cells dose‐dependently at concentrations from 30 to 1OOO μg/ml.
Fumio Kuzuya, Kanichi Asai, Michitaka Naito, Toshio Hayashi, Masafumi Kuzuya, Chiaki Funaki   +5 more
openaire   +3 more sources