Results 61 to 70 of about 419,114 (213)

Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis

Frontiers in Bioscience-Landmark, 2020
Hyperhomocysteinemia induces stress response in endoplasmic reticulum (ERS). Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by blockage of PERK/eIF2α/ATF4/CHOP ...
Wei Li, Fujun Shang, Xiaoli Li, Shaoping Lu, Xiaolin Niu, Zhimin Zhang, Jing Liu, Xue Li, Lianyou Zhao   +8 more
doaj   +1 more source

Senescence in Vascular Smooth Muscle Cells and Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Vascular smooth muscle cells (VSMCs) are the primary cell type involved in the atherosclerosis process; senescent VSMCs are observed in both aged vessels and atherosclerotic plaques.
Yiwen Zha, Wenwen Zhuang, Yongqi Yang, Yue Zhou, Hongliang Li, Hongliang Li, Jingyan Liang, Jingyan Liang, Jingyan Liang   +8 more
doaj   +1 more source

Exogenous NG-hydroxy-l-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity [PDF]

, 1994
Nitric oxide (NO) production from exogenous NG-hydroxy-l-arginine (OH-l-Arg) was investigated in rat aortic smooth muscle cells in culture by measuring nitrite accumulation in the culture medium.
C.A. Schott, C.M. Bogen, P. Vetrovsky, C.C. Berton, J.C. Stoclet, Marletta, Stuehr, Klatt, Chenais, Wallace, Moncada, Fleming, Busse, Low, Stoclet, Wallace, Clapp, Gazzola, Cheng, Zembowicz, Boucher, Boucher, White, Schott, Rogers, Zembovicz, Gray   +26 more
core   +3 more sources

The Bone-Vascular Axis: A Key Player in Chronic Kidney Disease Associated Vascular Calcification

Kidney Diseases
Background: The bone-vascular axis plays a key role in the pathogenesis of vascular calcification (VC) in patients with chronic kidney disease (CKD). Understanding and managing the role of the bone-vascular axis in CKD-mineral and bone disorder (CKD-MBD)
Yingjing Shen, Chen Yu
doaj   +1 more source

Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-gamma and macrophage colony-stimulating factor in human aortic medial smooth muscle cells [PDF]

, 1995
Vascular medial smooth muscle cells migrate, proliferate and transform to foam cells in the process of atherosclerosis. We have reported that the intimal smooth muscle cells express proto-oncogene c-fms, a characteristic gene of monocyte-macrophages ...
Gotoda Takanari, Harada Kenji, Inaba Toshimori, Ishibashi Shun, Ohsuga Jun-ichi, Shimada Masako, Yamada Nobuhiro, Yazaki Yoshio, 山田 信博   +8 more
core   +1 more source

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway

Nature Communications, 2017
The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 ...
Ning Xie, Min Chen, Rilei Dai, Yan Zhang, Hanqing Zhao, Zhiming Song, Lufeng Zhang, Zhenyan Li, Yuanqing Feng, Hua Gao, Li Wang, Ting Zhang, Rui-Ping Xiao, Jianxin Wu, Chun-Mei Cao   +14 more
doaj   +1 more source

Prdm6 is essential for cardiovascular development in vivo.

PLoS ONE, 2013
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system.
Andreas Gewies, Mercedes Castineiras-Vilarino, Uta Ferch, Nina Jährling, Katja Heinrich, Ulrike Hoeckendorf, Gerhard K H Przemeck, Matthias Munding, Olaf Groß, Timm Schroeder, Marion Horsch, E Loraine Karran, Aneela Majid, Stefan Antonowicz, Johannes Beckers, Martin Hrabé de Angelis, Hans-Ulrich Dodt, Christian Peschel, Irmgard Förster, Martin J S Dyer, Jürgen Ruland   +20 more
doaj   +1 more source

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]

, 1987
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Koch, K. M., Kurtz, Armin, Kühn, K., Pfeilschifter, J.   +3 more
core   +1 more source