Results 41 to 50 of about 236,796 (264)

The regulation of vascular smooth muscle cell apoptosis [PDF]

Cardiovascular Research, 2000
Apoptosis describes the morphological changes that identify a specific form of regulated cell death. Over recent years, the importance of either aberrant onset or suppression of apoptosis within tissues has become apparent and is associated with the development of several terminal diseases. Here we describe the relevance of apoptosis to the maintenance
N J, McCarthy, M R, Bennett
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.

PLoS Genetics, 2019
As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston, Lei Zeng, Abidemi Onabadejo, Sarah J Childs   +3 more
doaj   +1 more source

Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors

Frontiers in Cell and Developmental Biology, 2021
Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine.
Blerina Ahmetaj-Shala, Isra Marei, Isra Marei, Ryota Kawai, Ryota Kawai, Stephen Rothery, Charis Pericleous, Nura A. Mohamed, Nura A. Mohamed, Hime Gashaw, Kalliopi Bokea, Jake Samuel, Annabelle Vandenheste, Fisnik Shala, Nicholas S. Kirkby, Jane A. Mitchell   +15 more
doaj   +1 more source

Vascular Smooth Muscle Cells in the Pathogenesis of Vascular Calcification [PDF]

Circulation Research, 2009
See related article, pages 733–741 Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. In atherosclerotic lesions, calcification is mainly found in the neointima of atheromatous plaques and has been shown to positively correlate with the plaque burden and the risk of myocardial infarction.
openaire   +2 more sources

Quantification of alignment of vascular smooth muscle cells [PDF]

Cytometry Part A, 2018
AbstractVascular smooth muscle cells (VSMCs) are essential components that keep the tonus of the arterial network, which is the channel used to conduct the blood from the heart to the peripheral areas of the body. It is known that mechanical and architectural changes in VSMCs may lead to functional modifications in the cardiovascular system; therefore,
Marcel P, Dorta, Isis V, de Brito, Alexandre C, Pereira, Adriano M, Alencar   +3 more
openaire   +2 more sources

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Gasdermin D affects aortic vascular smooth muscle cell pyroptosis and Ang II-induced vascular remodeling

Heliyon, 2023
Vascular smooth muscle cells (VSMCs) are primarily responsible for vasoconstriction and the regulation of blood pressure1. Pyroptosis, a particular form of regulated cell death, is involved in multiple vascular injuries, including hypertensive vascular ...
Zimin Fang, Gaojun Wu, Jian Sheng, Bozhi Ye, Zhouqing Huang, Jianjiang Xu, Jianqin Zhang, Jibo Han, Bingjiang Han, Jiajun Xu   +9 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Guidance Molecules in Vascular Smooth Muscle

Frontiers in Physiology, 2018
Several highly conserved families of guidance molecules, including ephrins, Semaphorins, Netrins, and Slits, play conserved and distinct roles in tissue remodeling during tissue patterning and disease pathogenesis.
Alexandra Christine Finney, Anthony Wayne Orr, Anthony Wayne Orr, Anthony Wayne Orr   +3 more
doaj   +1 more source