Results 31 to 40 of about 236,010 (265)

Caveolin-3 promotes a vascular smooth muscle contractile phenotype

Frontiers in Cardiovascular Medicine, 2015
Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle cells are believed to play an essential role in the development of ...
Jorge L. Gutierrez-Pajares, Jeannette eIturrieta, Vipin eDulam, Yu eWang, Yu eWang, Stephanos ePavlides, Gabriella eMalacari, Michael P. Lisanti, Philippe G. Frank   +8 more
doaj   +1 more source

Proliferation and apoptosis of smooth muscle and endothelial cells with immune inflammation in cerebrovascular diseases on atherosclerosis background [PDF]

Romanian Journal of Neurology, 2022
The aim – to determine the role of vascular wall cells proliferation and apoptosis with the participation of immune inflammation, and their impact on the development of cerebrovascular disease (CVD) development on the atherosclerosis (AS) background ...
D.S. Mankovskiy, N.Ya. Chuiko, O.G. Kuryk   +2 more
doaj   +1 more source

α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies

Brazilian Journal of Cardiovascular Surgery, 2015
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse
Shi-Min Yuan
doaj   +1 more source

Endothelial cell-derived extracellular vesicles alter vascular smooth muscle cell phenotype through high-mobility group box proteins

Journal of Extracellular Vesicles, 2020
The vascular endothelium and smooth muscle form adjacent cellular layers that comprise part of the vascular wall. Each cell type can regulate the other’s structure and function through a variety of paracrine effectors.
Michael J. Boyer, Yayoi Kimura, Tomoko Akiyama, Ariele Y. Baggett, Kyle J. Preston, Rosario Scalia, Satoru Eguchi, Victor Rizzo   +7 more
doaj   +1 more source

Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]

PLoS ONE, 2012
Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang, Ning Zhao, Simone Kennard, Brenda Lilly   +3 more
doaj   +1 more source

Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation

Pharmaceutical Biology, 2023
Context Gastrodin has been used as antihypertension therapy in China; however, the mechanisms underlying the effects of gastrodin have yet to be fully elucidated.Objective To explore the therapeutic efficiency of gastrodin as an antihypertensive and ...
Zhi Guo, Xuan Yang, Meizhu Wu, Aling Shen, Jiapeng Li, Xiuli Zhang, Ying Cheng, Qiurong Xie, Jun Peng   +8 more
doaj   +1 more source

Regulation of vascular smooth muscle cell differentiation [PDF]

Journal of Vascular Surgery, 2007
Vascular smooth muscle cell (VSMC) differentiation is an essential component of vascular development. These cells perform biosynthetic, proliferative, and contractile roles in the vessel wall. VSMCs are not terminally differentiated and are able to modulate their phenotype in response to changing local environmental cues.
Rzucidlo, Eva M., Martin, Kathleen A., Powell, Richard J.   +2 more
openaire   +2 more sources

Characterization of ectonucleotidases on vascular smooth-muscle cells [PDF]

Biochemical Journal, 1985
We compared the properties of the ectonucleotidases (nucleoside triphosphatase, EC 3.6.1.15; nucleoside diphosphatase, EC 3.6.1.6; 5′-nucleotidase, EC 3.1.3.5) in intact pig aortic smooth-muscle cells in culture with the properties that we previously investigated for ectonucleotidases of aortic endothelial cells [Cusack, Pearson & Gordon (1983 ...
J D, Pearson, S B, Coade, N J, Cusack
openaire   +2 more sources

Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells

Stem Cell Reports, 2019
Summary: Vascular smooth muscle cells (vSMCs) are highly heterogeneous across different vascular beds. This is partly dictated by their developmental origin but also their position in the vascular tree, reflected in their differential responses to ...
Oleh V. Halaidych, Amy Cochrane, Francijna E. van den Hil, Christine L. Mummery, Valeria V. Orlova   +4 more
doaj   +1 more source

Vascular smooth muscle cell senescence in atherosclerosis [PDF]

Cardiovascular Research, 2006
Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo.
Isabelle, Gorenne, Mary, Kavurma, Stephen, Scott, Martin, Bennett   +3 more
openaire   +2 more sources