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Vascular Stiffness in Aging and Disease [PDF]
Frontiers in Physiology, 2021 The goal of this review is to provide further understanding of increased vascular stiffness with aging, and how it contributes to the adverse effects of major human diseases.
Stephen F. Vatner +5 more
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Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Signal Transduction and Targeted TherapyCardiovascular diseases are the leading cause of morbidity and mortality worldwide. The central underlying mechanisms of cardiovascular diseases are vascular aging and associated arterial stiffness. Arterial stiffness is characterized by structural (e.g.,
Maximilian Jonathan Herzog +9 more
doaj +6 more sources
Targeting Vascular Stiffness. [PDF]
Arterioscler Thromb Vasc BiolArtery stiffening, a biomechanical vascular property closely related to but separate from hypertension, is a strong and independent cardiovascular disease risk factor that also predicts end-organ failure. Decreased aortic compliance elevates the mechanical load on the myocardium, increases peripheral pulse pressure which damages high-flow organs ...
Mack CP.
europepmc +4 more sources
Inhibition of the histone methyltransferase EZH2 induces vascular stiffness. [PDF]
Clin Sci (Lond), 2023 Vascular stiffness increases with aging, obesity and hypertension and predicts cardiovascular risk. The levels of histone H3-lysine-27 methylation(H3K27me) and the histone methyltransferase EZH2 both decrease in aging vessels, driving vascular stiffness.
Ibarrola J +5 more
europepmc +4 more sources
Association of the human gut microbiota with vascular stiffness. [PDF]
Sci Rep, 2023 Gut microbiota metabolites have been mechanistically linked to inflammatory pathway activation and atherosclerosis, which are major causes of vascular stiffness (VS).
Cuadrat RRC +8 more
europepmc +9 more sources
Vascular Stiffness in Insulin Resistance and Obesity [PDF]
Frontiers in Physiology, 2015 Obesity, insulin resistance, and type 2 diabetes are associated with a substantially increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of cardiovascular and chronic kidney disease.
Guanghong eJia +5 more
doaj +5 more sources
Inter- and intradialytic fluid volume changes and vascular stiffness parameters in patients on hemodialysis. [PDF]
PLoS ONE, 2022 BackgroundWhether fluid overload is associated with vascular stiffness parameters in hemodialysis (HD) patients has not been fully elucidated. We hypothesized that interdialytic fluid accumulation increases vascular stiffness parameters, which improves ...
Aya Lafta +6 more
doaj +3 more sources
Vascular aging, the vascular cytoskeleton and aortic stiffness [PDF]
Exploration of Medicine, 2021 Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell (VSMC).
Lova Prasadareddy Kajuluri +2 more
doaj +4 more sources
Frontiers in Vascular Stiffness
, 2023 The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and ...
Paolo Salvi, Andrea Grillo
semanticscholar +3 more sources
Vascular Aging and Arterial Stiffness
Arquivos Brasileiros de Cardiologia, 2017 Cardiovascular diseases (CVD) account annually for almost one third of all deaths worldwide. Among the CVD, systemic arterial hypertension (SAH) is related to more than half of those outcomes.
Luana de Rezende Mikael +8 more
doaj +5 more sources