Results 71 to 80 of about 560,736 (342)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Evaluation of Ingenol mebutate efficacy for the treatment of actinic keratosis with Antera 3D camera [PDF]

, 2015
OBJECTIVE: Cumulative exposure of the skin to ultraviolet radiation promotes mutation in keratinocytes and their abnormal growth led to the formation of scaly lesions, called actinic keratoses (AKs).
Bottoni, U, Calvieri, S., Cantisani, Carmen, Corsetti, P, Didona, D, Paolino, G   +5 more
core  

Vascular Dementia [PDF]

Current Translational Geriatrics and Experimental Gerontology Reports, 2013
The purpose of this review is to highlight existing literature on the epidemiology, pathophysiology, and novel risk factors for vascular dementia. We further examine the evidence linking chronic brain hypoperfusion induced by a variety of cardiovascular diseases to the development of vascular dementia.
Alberto R, Ramos, Salim I, Dib, Clinton B, Wright   +2 more
openaire   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biofabrication of 3D-printed, pre-cross-linked alginate dialdehyde–gelatin (ADA–GEL) scaffolds for an in vivo metastatic arteriovenous loop tumor model

Frontiers in Bioengineering and Biotechnology
Vascularized models mimicking tumor pathophysiology to investigate tumor characteristics are of high interest. The arteriovenous loop (AVL) model is an established method to vitalize bioengineered tissue grafts. In this model, an artificial vascular axis
Evelin Sandor, Tannaz Karimi, Rafael Schmid, Yvonne Kulicke, Stefanie Heltmann-Meyer, Carolin Eckert, Sonja K. Schmidt, Jonas Röder, Markus V. Heppt, Markus V. Heppt, Aldo R. Boccaccini, Raymund E. Horch, Anja K. Boßerhoff, Annika Kengelbach-Weigand, Andreas Arkudas   +14 more
doaj   +1 more source

Optimization of Co-Culture Conditions for a Human Vascularized Adipose Tissue Model

Bioengineering, 2020
In vitro adipose tissue models can be used to provide insight into fundamental aspects of adipose physiology. These systems may serve as replacements for animal models, which are often poor predictors of obesity and metabolic diseases in humans.
Feipeng Yang, Ronald N. Cohen, Eric M. Brey   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

In Vitro Free Implantation of Stem Cells from Apical Papilla Using Injectable Hydrogel‐Laden 3D‐Printed Scaffold to Enhance Tissue Organization and Vascular Infiltration In Vivo

Advanced NanoBiomed Research
In emergency situations involving the loss of hard tissues, immediate treatment is crucial. While 3D‐printed scaffolds offer structural support for damaged tissue, the processes of tissue integration and blood vessel formation remain challenging.
Ziqi Huang, Chao Liang, Zhenzhen Wu, Siyuan Chen, Feiming Li, Kiho Cho, Woo‐Youl Maeng, Yeon‐Hee Lee, Su A. Park, Yeong‐Jin Choi, Hui‐suk Yun, Soo‐Hong Lee, Donghyun Lee, Sang‐Hyun An, Jae Beum Bang, Sang Jin Lee   +15 more
doaj   +1 more source

In Vivo Vascularization of Cell-Supplemented Spider Silk-Based Hydrogels in the Arteriovenous Loop Model

Biomimetics
The goal of reconstructive surgery in treating tissue defects is to achieve a stable reconstructive outcome while minimizing donor site morbidity. As a result, tissue engineering has emerged as a key focus in the pursuit of this goal.
Justus Osterloh, Stefanie Heltmann-Meyer, Vanessa T. Trossmann, Aijia Cai, Yvonne Kulicke, Klara Terörde, Celena A. Sörgel, Isabell Lang, Harald Wajant, Thomas Scheibel, Tobias Fey, Dominik Steiner, Andreas Arkudas, Raymund E. Horch   +13 more
doaj   +1 more source