Results 121 to 130 of about 82,899 (261)

Clostridium difficile suppresses colonic vasoactive intestinal peptide associated with altered motility

Mediators of Inflammation, 1995
We investigated whether Clostridium difficile toxin alters colonic tissue levels of vasoactive intestinal peptide (VIP) at the expense of changes in colonic motility in the isolated perfused rabbit left colon.
A. Nassif, W. E. Longo, R. Sexe, M. Stratton, J. Standeven, A. M. Vernava, D. L. Kaminski   +6 more
doaj   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex

Frontiers in Neuroanatomy, 2014
In both humans and rodents, decline in cognitive function is a hallmark of the aging process, the basis for this decrease has yet to be fully characterized.
Lydia eOuellet, Etienne ede Villers-Sidani   +1 more
doaj   +1 more source

Heat Therapy: Targeting Health, Disease, and Disability

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
The predominance of evidence suggests heat therapy has an impact on all aspects of health and performance, but the drivers of that improvement, the extent to which they are improved, and the specific populations in which improvements manifest are far from completely understood.
Rauchelle E. Richey, Robert D. Hyldahl, Brendan W. Kaiser, Paige C. Geiger, John R. Halliwill, Christopher T. Minson   +5 more
wiley   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

The Vascular‐Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
This review synthesizes current evidence showing how vascular–immune cell crosstalk and microenvironmental cues shape pulmonary vascular remodeling in pulmonary hypertension. We provide an integrative perspective that positions disrupted cellular communication as a central driver of disease progression and a promising source of future therapeutic ...
Lola Navarro‐Llinares, Bertha García‐León, Laura de la Bastida‐Casero, Eduardo Oliver   +3 more
wiley   +1 more source

Distinguishing Features of ILC2s During Type 2 Immune Responses

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Group 2 innate lymphoid cells (ILC2s) are tissue‐resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections.
Manuel O. Jakob, Patrycja M. Forster, Christoph S. N. Klose   +2 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Prolonged survival in a young Dobermann with adrenal neuroblastoma

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 1‐year‐old Dobermann presented with recurrent episodes of acute diarrhoea and weight loss starting at 5 months of age. An adrenal mass was identified via ultrasound and computed tomography, leading to adrenalectomy. A diagnosis of adrenal neuroblastoma was obtained through histopathology and immunohistochemistry.
Nataliia Ignatenko, Sara Soto, Tamara Weitzer, Irina Abramenko, Johannes Hirschberger, Ivan Stoikov, Galyna Mazurkevych, Dmytro Litvinenko, Ralf S. Mueller   +8 more
wiley   +1 more source

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 124-135, February 2026.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
wiley   +1 more source