Results 61 to 70 of about 1,523,943 (289)

The dynamic selection of coordination mechanisms

, 2004
This paper presents and evaluates a decision making framework that enables autonomous agents to dynamically select the mechanism they employ in order to coordinate their inter-related activities. Adopting this framework means coordination mechanisms move
Jennings, N. R., Excelente-Toledo, CB, Excelente-Toledo, C.B., Jennings, NR   +3 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Prophylactic Intravenous Phenylephrine to Prevent Propofol-induced Hypotension during Induction of General Anaesthesia: A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Propofol is commonly used intravenous induction agent which are frequently complicated by peri-induction hypotension. Reduced Mean Arterial Pressure (MAP) during anaesthesia contributes to significant postoperative morbidity, including ...
Sagar Harishchandra Pawar, Vijaykumar T Kallyanappagol, Santoshkumar Alalamath   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Trajectories of mean arterial pressure/norepinephrine equivalent dose index in patients with septic shock receiving low-dose hydrocortisone: a retrospective cohort study in Thailand [PDF]

Acute and Critical Care
Background We aimed to analyze the trajectories of the mean arterial pressure/norepinephrine equivalent dose (MAP/NEQ) index in patients with septic shock treated with low-dose hydrocortisone and to determine the association of these trajectories with ...
Auttawut Chalermwutanon, Sawangjit Saejaow, Veerapong Vattanavanit   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

USE OF FLUIDS AND VASOPRESSORS IN THE PREVENTION AND MANAGEMENT OF THE SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING SCHEDULED CESAREAN SECTION IN COLOMBIAN WOMEN (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: during the scheduled cesarean section, the main side effect of the spinal anesthesia is the spinal anesthesia-induced hypotension (SAIH).
Marrugo-Marrugo José, Granados-Vergara Lina, Marrugo-Vergara Jahaira   +2 more
doaj  

Prediction of vasopressor needs in hypotensive emergency department patients using serial arterial blood pressure data with deep learning

Hong Kong Journal of Emergency Medicine
Background Shock is a life‐threatening condition that is associated with high mortality and morbidity. Therefore, the timely identification and management of this condition are important.
Yeongho Choi, Ki Hong Kim, Yoonjic Kim, Dong Hyun Choi, Yoon Ha Joo, Sae Won Choi, Kyoung Jun Song, Sang Do Shin   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Inhibitory effect of hypertonic mannitol on vasoconstrictor and vasodilator responses of isolated coronary arteries

, 1978
The effect of hypertonic mannitol on pressor responses to vasoactive agents was studied in isolated canine coronary arteries perfused with physiologic salt solution at a constant flow.
G. H. Templeton, V. S. Krishnamurty, H. R. Adams, J. T. Willerson   +3 more
core   +1 more source