Results 71 to 80 of about 33,455 (307)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Prophylactic Intravenous Phenylephrine to Prevent Propofol-induced Hypotension during Induction of General Anaesthesia: A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Propofol is commonly used intravenous induction agent which are frequently complicated by peri-induction hypotension. Reduced Mean Arterial Pressure (MAP) during anaesthesia contributes to significant postoperative morbidity, including ...
Sagar Harishchandra Pawar, Vijaykumar T Kallyanappagol, Santoshkumar Alalamath   +2 more
doaj   +1 more source

Diabetes mellitus and ischemic heart disease. the role of ion channels [PDF]

, 2018
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic ...
De Marchis, Marialaura, D’Amato, Andrea, Fedele, Francesco, Mancone, Massimo, Netti, Lucrezia, Palmirotta, Raffaele, Pucci, Mariateresa, Severino, Paolo, Volterrani, Maurizio   +8 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined.
Zahra Gholamnezhad, Zahra Fatehi Hassanabad   +1 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

USE OF FLUIDS AND VASOPRESSORS IN THE PREVENTION AND MANAGEMENT OF THE SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING SCHEDULED CESAREAN SECTION IN COLOMBIAN WOMEN (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: during the scheduled cesarean section, the main side effect of the spinal anesthesia is the spinal anesthesia-induced hypotension (SAIH).
Marrugo-Marrugo José, Granados-Vergara Lina, Marrugo-Vergara Jahaira   +2 more
doaj  

LOCAL ANESTHETICS IN PATIENTS WITH CARDIOVASCULAR DISEASES. [PDF]

Journal of IMAB, 2015
A significant problem in the dental medicine is pain alleviation. Many studies in the dental anesthesiology result in the production of new agents for locoregional anesthesia.
risto Daskalov, Atanaska Dinkova, Martin Drangov   +2 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CURRENT ASPECTS OF USE OF NASAL VASOCONSTRICTORS AND ADJUNCTIVE AGENTS IN PEDIATRIC PRACTICE

Медицинский совет, 2018
Nasal forms of vasoconstrictor agents (decongestants) are one of the most frequently prescribed groups of drugs in the therapy of inflammatory diseases of the nasal cavity.
D. A. Tulupov, F. A. Fedotov, E. P. Karpova, V. A. Grabovskaya   +3 more
doaj   +1 more source