Results 51 to 60 of about 1,523,943 (289)
Modern views on the molecular and vascular mechanisms of preeclampsia
Ukrainian Scientific Medical Youth Journal, 2022 the article summarizes the arguments and counterarguments in the scientific discussion on the mechanisms of preeclampsia. The main purpose of this study is to summarize information about the molecular and vascular mechanisms of preeclampsia.
Tetiana Shumilina, Yaroslava Slyvka
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Pulmonary vasoconstrictor reactivity following intermittent hypoxia [PDF]
, 2009 Sleep apnea (SA) affects as many as 20% of the adult population in the United States. It elicits intermittent hypoxia (IH) and causes pulmonary hypertension (PH), however the mechanisms of this PH have not been well studied.
Snow, Jessica
core +1 more source
Vasoplegia treatments: the past, the present, and the future
Critical Care, 2018 Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving various mechanisms in vascular smooth muscle cells such as G protein-coupled
Bruno Levy +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Terlipressin-related Ischaemic Necrosis of the Skin: A Rare Complication
European Journal of Case Reports in Internal Medicine, 2019 Terlipressin is used for the treatment of bleeding oesophageal varices and hepatorenal syndrome in patients with cirrhosis. Adverse effects are usually minimal.
Sara Simões Macedo +4 more
doaj +1 more source
Beyond autonomy : the self and life of social agents
, 2019 Agents have gained popularity nowadays as virtual assistants and companions of their human users supporting daily activities in many aspects of personal life.
Tan, Ah-Hwee, Subagdja, Budhitama
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The efficacy of hyperbaric oxygen therapy for skin perfusion following peripheral tissue injury due to usage of inotropes and vasopressors: a case report [PDF]
Clinical and Experimental Emergency MedicineHyperbaric oxygen therapy (HBOT) has garnered significant attention as a therapeutic modality with potential benefits across a variety of medical conditions, ranging from wound healing and ischemic conditions to neurologic disorders and radiation-induced
Nien Hsiu Suen +4 more
doaj +1 more source
Responsiveness to Vasoconstrictor and Dilator Agents of Senescent Beagle Cerebral Arteries
Japanese Journal of Pharmacology, 1986 With advancing age from 2 to 12 years, contractions of isolated beagle cerebral arteries mediated by histamine H1 and serotonin receptors increased, whereas those induced by noradrenaline and angiotensin II did not differ. Relaxations by vasodilator substances, such as prostaglandin (PG) I2, isoproterenol, adenosine and K+ (5 mM), and by stimulation of
SHIMIZU, Ikuko +2 more
openaire +3 more sources