Results 51 to 60 of about 19,340 (257)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

USE OF FLUIDS AND VASOPRESSORS IN THE PREVENTION AND MANAGEMENT OF THE SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING SCHEDULED CESAREAN SECTION IN COLOMBIAN WOMEN (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: during the scheduled cesarean section, the main side effect of the spinal anesthesia is the spinal anesthesia-induced hypotension (SAIH).
Marrugo-Marrugo José, Granados-Vergara Lina, Marrugo-Vergara Jahaira   +2 more
doaj  

Effects of lipopolysaccharide-induced septic shock on rat isolated kidney, possible role of nitric oxide and protein kinase C pathways [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined.
Zahra Gholamnezhad, Zahra Fatehi Hassanabad   +1 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CURRENT ASPECTS OF USE OF NASAL VASOCONSTRICTORS AND ADJUNCTIVE AGENTS IN PEDIATRIC PRACTICE

Медицинский совет, 2018
Nasal forms of vasoconstrictor agents (decongestants) are one of the most frequently prescribed groups of drugs in the therapy of inflammatory diseases of the nasal cavity.
D. A. Tulupov, F. A. Fedotov, E. P. Karpova, V. A. Grabovskaya   +3 more
doaj   +1 more source

LOCAL ANESTHETICS IN PATIENTS WITH CARDIOVASCULAR DISEASES. [PDF]

Journal of IMAB, 2015
A significant problem in the dental medicine is pain alleviation. Many studies in the dental anesthesiology result in the production of new agents for locoregional anesthesia.
risto Daskalov, Atanaska Dinkova, Martin Drangov   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Prediction of vasopressor needs in hypotensive emergency department patients using serial arterial blood pressure data with deep learning

Hong Kong Journal of Emergency Medicine
Background Shock is a life‐threatening condition that is associated with high mortality and morbidity. Therefore, the timely identification and management of this condition are important.
Yeongho Choi, Ki Hong Kim, Yoonjic Kim, Dong Hyun Choi, Yoon Ha Joo, Sae Won Choi, Kyoung Jun Song, Sang Do Shin   +7 more
doaj   +1 more source

The Role of Adjuvant Acid Suppression on the Outcomes of Bleeding Esophageal Varices after Endoscopic Variceal Ligation.

PLoS ONE, 2017
The impact of adjuvant acid suppression via proton pump inhibitors or histamine-2 receptor antagonists after endoscopic variceal ligation remains uncertain.
Cheng-Kun Wu, Chih-Ming Liang, Chien-Ning Hsu, Tsung-Hsing Hung, Lan-Ting Yuan, Seng-Howe Nguang, Jiunn-Wei Wang, Kuo-Lun Tseng, Ming-Kun Ku, Shih-Cheng Yang, Wei-Chen Tai, Chih-Wei Shih, Pin-I Hsu, Deng-Chyang Wu, Seng-Kee Chuah   +14 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source