Results 91 to 100 of about 115,075 (345)
Critical Care Medicine, 2014 Objectives:Vasopressin and corticosteroids are both commonly used adjunctive therapies in septic shock. Retrospective analyses have suggested that there may be an interaction between these drugs, with higher circulating vasopressin levels and improved ...
A. Gordon +6 more
semanticscholar +1 more source
Special Collection: Women of Catalysis 2024 NADH Driven Enzymatic Carboxylic Acid Reduction
ChemCatChem, Accepted Article.Carboxylic acid reductases (CARs) are versatile biocatalysts for aldehyde production from carboxylic acids. The redox co‐factor utilized by CARs is NADPH and no explicitly NADH dependent CARs have been described so far. Especially in view of cell free applications which necessitate cofactor recycling, NADH dependent enzymes are more appealing due to ...
Jonathan Guyang Ling +4 more
wiley +1 more source
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Journal of neuroendocrinology, 2012 We recently reviewed the status of peptide and nonpeptide agonists and antagonists for the V1a, V1b and V2 receptors for arginine vasopressin (AVP) and the oxytocin receptor for oxytocin (OT).
M. Manning +11 more
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.The in‐situ generation of Grignard‐type organocalcium reagents via the reduction of alkyl and aryl halides in THF and their immediate use for subsequent addition onto carbodiimides allows the synthesis of hitherto unknown amidinates of calcium. Abstract The in‐situ Grignard addition method adds intermediately prepared organo alkaline‐earth metal ...
Simon Sengupta +3 more
wiley +1 more source
Vasopressin and Terlipressin in the Treatment of Vasodilatory Septic Shock: A Systematic Review
Proceedings of Singapore Healthcare, 2011 Background: Vasodilatory septic shock unresponsive to fluid resuscitation requires the addition of vasopressors. Catecholamines remain the first line vasopressor therapy, but treatment failure is a potential problem.
Jie Lin Soong BSc (Pharm) (Hons) +1 more
doaj +1 more source
Critical Care Medicine, 2014 Objective:To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective as the mixed vasopressin type 1a receptor/vasopressin V2 receptor agonist vasopressor hormone arginine vasopressin when used as a ...
M. Maybauer +14 more
semanticscholar +1 more source
ChemPlusChem, EarlyView.Novel enzyme‐modified carbon felt electrodes are constructed for efficient bio‐electrocatalysis. Simultaneous electrodeposition of pyrrole and neutral red provides a facile one‐step approach for enzyme immobilization. The biocompatible conductive polymer matrix performs for the entrapment of dehydrogenase enzymes on the electrode and ensures sufficient
Hathaichanok Seelajaroen +6 more
wiley +1 more source
The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines
Biology of the Cell, Volume 115, Issue 1, January 2023., 2023 Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a pathology characterised by the formation of kidney cists that impair renal function. The wall of renal cysts is covered with cystic cells that show increased activation of mTOR. Abnormal mTOR activation inhibits autophagy, promotes the degradation of TP53 by the proteasome in a mechanism ...
Simone Patergnani +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source