Results 51 to 60 of about 808 (137)

Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice

Acta Physiologica, Volume 240, Issue 4, April 2024.
Abstract Aim Protein disulfide isomerases (PDIs) are involved in platelet aggregation and intravascular thrombosis, but their role in regulating endothelial function is unclear. Here, we characterized the involvement of vascular PDIA1 in angiotensin II (Ang II)‐induced endothelial dysfunction in mice.
Agnieszka Kij, Anna Bar, Izabela Czyzynska‐Cichon, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Zuzanna Kurylowicz, Agnieszka Jasztal, Elzbieta Buczek, Anna Kurpinska, Joanna Suraj‐Prazmowska, Brygida Marczyk, Karolina Matyjaszczyk‐Gwarda, Andreas Daiber, Matthias Oelze, Maria Walczak, Stefan Chlopicki   +16 more
wiley   +1 more source

Pulmonary arterial hypertension: Sex matters

British Journal of Pharmacology, Volume 181, Issue 7, Page 938-966, April 2024.
▪▪ Pulmonary arterial hypertension (PAH) is a complex disease of multifactorial origin. While registries have demonstrated that women are more susceptible to the disease, females with PAH have superior right ventricle (RV) function and a better prognosis than their male counterparts, a phenomenon referred to as the ‘estrogen paradox’.
Joshua P. Dignam, Smriti Sharma, Ioannis Stasinopoulos, Margaret R. MacLean   +3 more
wiley   +1 more source

The differential sensitivity of the hypothalamic–hypophysial–ovarian axis to 5‐hydroxytryptophan alters the secretion of estradiol

Experimental Physiology, Volume 109, Issue 3, Page 365-379, 1 March 2024.
Abstract Serotonin [5‐hydroxytryptamine (5‐HT)] modulates ovarian function. The precursor of 5‐HT, 5‐hydroxytryptophan (5‐HTP), has been used to treat depression. However, the effects of 5‐HTP on ovarian and reproductive physiology remain unknown. In this research, we analysed the impact of 5‐HTP on the monoaminergic system and its interactions with ...
Juana Monroy, Omar D. Cortés, Roberto Domínguez, María Eugenia Mendoza‐Garrido, Eloir Gallegos, Mario Cárdenas, Andrés Aragón, María E. Ayala   +7 more
wiley   +1 more source

Vasoprotection by melatonin and quercetin in rats treated with cisplatin

, 2010
Cisplatin-based chemotherapy has a variety of vascular side effects. The aim of the present study was to evaluate the beneficial effect of melatonin and cisplatin on the alterations in vascular reactivity and structure of cisplatin-treated rats ...
Keles, B., Dundar, M. A., Uyar, Y., Esen, H. H., Oz, M., Atalik, K. E.   +5 more
core   +1 more source

Vasoprotection by Dietary Supplements and Exercise: Role of TNFαSignaling [PDF]

, 2012
Vascular dysfunction contributes to the pathogenesis of various cardiovascular diseases. Dietary supplements, including fish oil, dietary fibers, and various natural products, and exercise training exert vasoprotective effects.
Hanrui Zhang, Cuihua Zhang
core   +1 more source

Saphenous vein graft and nitric oxide: strategies to prevent graft failure and enhance patency in coronary artery bypass grafting

Frontiers in Cardiovascular Medicine
Nitric oxide (NO) is a central regulator of vascular homeostasis and a key determinant of saphenous vein graft (SVG) outcomes in coronary artery bypass grafting (CABG).
Michele Dell’Aquila, Sotirios Prapas, Giorgia Falco, Shadi Abdalla, Branden Tejada, Meher Challagalla, Ignazio Condello, Joshua Newman, Omar Jarral, Stevan Pupovac, Ameerah Ali, Konstantinos Katsavrias, Augusto D’Onofrio, Carlo Zebele, Antonio Totaro, Vincenzo Labriola, Tulio Caldonazo, Hristo Kirov, Antonino Di Franco, Jordan Leith, Lisa Rong, Mohammed Rahouma, Derek Brinster, Alexander Iribarne, Frank Manetta, Nirav Patel, Robert Kalimi, Mario Gaudino, Antonio Maria Calafiore   +28 more
doaj   +1 more source

Endothelial nitric oxide synthase gene transfer restores endothelium–dependent relaxations and attenuates lesion formation in carotid arteries in apolipoprotein E–deficient mice [PDF]

, 2005
Nitric oxide (NO) and monocyte chemoattractant protein–1 (MCP-1) exert partly opposing effects in vascular biology. NO plays pleiotropic vasoprotective roles including vasodilation and inhibition of platelet aggregation, smooth muscle cell proliferation,
Kappenberger, Lukas, Segesser, Ludwig K. von, Vassalli, Giuseppe, Ming, Xiu-Fen, Viswambharan, Hema, Driscoll, Robert, Mujynya-Ludunge, Kathi, Yang, Zhihong   +7 more
core  

Image2_Troxerutin Stimulates Osteoblast Differentiation of Mesenchymal Stem Cell and Facilitates Bone Fracture Healing.TIF

, 2021
Troxerutin (TRX), a semi-synthetic derivative of the natural bioflavonoid rutin, is a bioactive flavonoid widely abundant in various fruits and vegetables.
Xiao Yang (19898), Xiao-Min Wu (745454), Xiao-Hua Pan (11248341), Jiang Shao (662374), Fei-Fei Pan (11248335), Shao-An Yang (11248338), An-Min Jin (11248344)   +6 more
core   +1 more source

DataSheet4_Troxerutin Stimulates Osteoblast Differentiation of Mesenchymal Stem Cell and Facilitates Bone Fracture Healing.ZIP

, 2021
Troxerutin (TRX), a semi-synthetic derivative of the natural bioflavonoid rutin, is a bioactive flavonoid widely abundant in various fruits and vegetables.
Xiao Yang (19898), Xiao-Min Wu (745454), Xiao-Hua Pan (11248341), Jiang Shao (662374), Fei-Fei Pan (11248335), Shao-An Yang (11248338), An-Min Jin (11248344)   +6 more
core   +1 more source

Contemporary, mechanism-anchored biomarkers of endothelial dysfunction and oxidative stress (established and emerging)

Journal of Education, Health and Sport
Background: Endothelial dysfunction and oxidative stress act together across hypertension, atherosclerosis, coronary disease and heart failure. Loss of nitric oxide (NO) signalling and excess reactive oxygen species (ROS) fuel inflammation, thrombosis ...
Katarzyna Skibicka, Weronika Wesołowska, Albert Jaśniak, Robert Bujak   +3 more
doaj   +1 more source