Results 41 to 50 of about 808 (137)

EVIDENCE-BASED CHOICE OF ACE INHIBITORS

Российский кардиологический журнал, 2012
Angiotensin-converting enzyme (ACE) inhibitors are currently one of the most frequently used groups of cardiovascular medications. In addition to wellknown indications, such as arterial hypertension (AH), chronic heart failure (CHF), and Type 2 diabetes ...
G. E. Gendlin, O. A. Miller, A. V. Melekhov   +2 more
doaj  

Advancing antihypertensive drug development

British Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

From Neurotransmission to Retinal Pathophysiology: Unraveling the Role of GABA Receptors in Retinal Disease Progression

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
GABA receptors, widely expressed in the retina, play a key role in lateral inhibition and synaptic regulation. Emerging evidence links their dysregulation to retinal diseases such as diabetic retinopathy, retinitis pigmentosa, glaucoma, and age‐related macular degeneration.
Alan E. Medina Arellano, Jesus Silvestre Albert‐Garay, Nadia Flores Huerta, Karla Tovar Hernández, Matilde Ruiz‐Cruz, Lenin Ochoa‐de la Paz   +5 more
wiley   +1 more source

TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiology has not been studied.
Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin   +4 more
wiley   +1 more source

Experimental therapies for glaucoma [PDF]

, 2014
W niniejszym artykule poglądowym omówiono, na podstawie aktualnej koncepcji patogenezy neuropatii jaskrowej, sześć kierunków przyszłej strategii terapii jaskry: baro-, wazo- i neuroprotekcję, terapię genową, medycynę regeneracyjną i immunoterapię ...
Wierzbowska, Joanna
core  

The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

Acta Medica Leopoliensia, 2019
The aim of our study was to evaluate nitrosooxidative status, the content of hydrogen sulphide and cortisol in blood serum of patients with a II stage arterial hypertension under the conditions of physical exertion. Material and Methods.Thirtypatients
I.S. Dronyk, O.Y. Yavorsky, O.Y. Sklyarov, R.S. Pshyk   +3 more
doaj   +1 more source

The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis

Clinical and Translational Medicine, Volume 15, Issue 3, March 2025.
We confirmed GI‐Y2 as a novel inhibitor of GSDMD. GI‐Y2 directly interacts with the Arg10 residue of GSDMD and reduces the membrane binding of GSDMD‐N. We constructed macrophage membrane‐coated GI‐Y2 nanoparticles to enhance the targeting of GI‐Y2 to macrophages in atheromatous plaques and demonstrated its vascular protective effect.
Xiaoxi Fan, Zhenfeng Cheng, Ruiyin Shao, Keke Ye, Xudong Chen, Xueli Cai, Shanshan Dai, Zhixuan Tang, Si Shi, Wenyuan Zheng, Weijian Huang, Jibo Han, Bozhi Ye   +12 more
wiley   +1 more source

Impact of thermal processing on polyphenols, carotenoids, glucosinolates, and ascorbic acid in fruit and vegetables and their cardiovascular benefits

Comprehensive Reviews in Food Science and Food Safety, Volume 23, Issue 6, November 2024.
Abstract Bioactive compounds in fruit and vegetables have a positive impact on human health by reducing oxidative stress, inflammation, and the risk of chronic diseases such as cancer, cardiovascular (CV) diseases, and metabolic disorders. However, some fruit and vegetables must be heated before consumption and thermal processes can modify the amount ...
Federica Narra, Eugenia Piragine, Giada Benedetti, Costanza Ceccanti, Marta Florio, Jacopo Spezzini, Fabiola Troisi, Roberto Giovannoni, Alma Martelli, Lucia Guidi   +9 more
wiley   +1 more source

Obeticholic Acid Inhibit Mitochondria Dysfunction Via Regulating ERK1/2‐DRP Pathway to Exert Protective Effect on Lipopolysaccharide‐Induced Myocardial Injury

Advanced Biology, Volume 8, Issue 7, July 2024.
OCA ameliorates lipopolysaccharide (LPS)‐induced myocardial injury in mice via improving mitochondria dysfunction. Further study indicates that suppression of ERK1/2‐DRP signaling is involving in OCA‐improved mitochondria dysfunction. Abstract Farnesoid X receptor (FXR) plays critical regulatory roles in cardiovascular physiology/pathology.
Huijie Miao, Xiaomeng Tang, Yun Cui, Jingyi Shi, Xi Xiong, Chunxia Wang, Yucai Zhang   +6 more
wiley   +1 more source

Puerarin mitigated LPS‐ATP or HG‐primed endothelial cells damage and diabetes‐associated cardiovascular disease via ROS‐NLRP3 signalling

Journal of Cellular and Molecular Medicine, Volume 28, Issue 10, May 2024.
Abstract The occurrence and development of diabetic vascular diseases are closely linked to inflammation‐induced endothelial dysfunction. Puerarin (Pue), the primary component of Pueraria lobata, possesses potent anti‐inflammatory properties. However, its vasoprotective role remains elusive.
Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Jin   +5 more
wiley   +1 more source