Results 31 to 40 of about 808 (137)

The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging

Frontiers in Physiology, 2019
Sirtuin1 (SIRT1), which belongs to a highly conserved family of protein deacetylase, is one of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including energy metabolism, cell proliferation and survival, chromatin ...
Andy W. C. Man, Huige Li, Ning Xia
doaj   +1 more source

Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice

Physiological Reports, 2022
Increased arterial stiffness is a cardiovascular disease risk factor in the setting of advancing age and Western diet (WD) induced obesity. Increases in large artery stiffness, as measured by pulse wave velocity (PWV), occur within 8 weeks of WD feeding ...
Venkateswara R. Gogulamudi, Daniel R. Machin, Grant D. Henson, Jisok Lim, Richard C. Bramwell, Jessica R. Durrant, Anthony J. Donato, Lisa A. Lesniewski   +7 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome.

PLoS ONE, 2022
BackgroundBy low-density lipoprotein (LDL) reduction, statins play an important role in cardiovascular risk modification. Incompletely understood pleiotropic statin effects include vasoprotection that might originate from mobilisation and differentiation
Roberta Florescu, Elisa Liehn, Nicole Schaaps, Jörg Schröder, Mohammad Almalla, Sebastian Mause, Anne Cornelissen, Felix Vogt   +7 more
doaj   +1 more source

Low Ethanol Concentrations Promote Endothelial Progenitor Cell Capacity and Reparative Function

Cardiovascular Therapeutics, 2020
Background. Endothelial progenitor cells (EPCs) are recruited to injured endothelium and contribute to its regeneration. There is evidence that moderate ethanol consumption prevents the development and progression of atherosclerosis in a variety of in ...
Lars Brodowski, Bianca Schröder-Heurich, Berina Kipke, Cara Schmidt, Constantin S. von Kaisenberg, Frauke von Versen-Höynck   +5 more
doaj   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase two results.

, 2001
L-Arginine may be a conditionally essential amino acid in children and adolescents with sickle cell disease, particularly as required substrate in the arginine-nitric oxide pathway for endogenous nitrovasodilation and vasoprotection.
Files, Beatrice A., McConnell, Michael E., Daeschner, Charles W. III, Waugh, William H., Strandjord, Sarah E.   +4 more
core   +2 more sources

Phenolic Compounds From Plant‐Based Material: Extraction and Biomedical Significance

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Phenolic compounds (PCs) are among the most widespread phytoconstituents found throughout the plant kingdom. These naturally occurring polyphenols have attracted remarkable scientific interest due to their potent antioxidant properties and their crucial role in mitigating oxidative stress‐related disorders, including cancer.
Amanpreet Kaur, Aayasha Negi, Pawan Kumar Shukla, Man Vir Singh, Aaysha Pandey, Neha Bhatt, Kamal Kishore   +6 more
wiley   +1 more source

Betahistine: targeting on vascular wall aging [PDF]

, 2019
Betahistine are routine drug in neurological practice, which is used to correct vertigo. The clinical efficacy of this drug can be caused not only by neuro-, but also by endotheliotropic action.
Sernov, L. N., Provotorov, V. Ya., Soldatov, V. O., Zapesotskaya, S. Ya., Pokrovskaya, T. G., Puchenkova, O. A., Feitelson, A. V., Pahlevanyan, V. G., Solgalova, A. S.   +8 more
core  

Bisphenol A‐Induced Vascular Endothelial Dysfunction: Protective Effects of Nigella sativa Oil and Thymoquinone

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
BPA exposure in rats and HUVECs impaired aortic contractility, increased lipid peroxidation, ROS, NO, VCAM‑1, and p‑eNOS, and blunted relaxant responses. Co‑treatment with NSO or TQ restored KCl/PE‑induced contractions, enhanced ACh‑ and SNP‑mediated vasorelaxation, and lowered oxidative/nitrosative stress and adhesion molecule expression.
Masoumeh Fadishei, Mahdieh Sadat Mohsenzadeh, Bibi Marjan Razavi, Mohsen Imenshahidi, Seyed Ahmad Mohajeri, Mahboubeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh   +6 more
wiley   +1 more source