Results 21 to 30 of about 808 (137)
CSE-Derived Hydrogen Sulfide Safeguards Vascular Iron Homeostasis by Coupling Ferritin Buffering to Vasoprotection. [PDF]
FASEB JWith iron overload, wild‐type (CSE+/+) mice upregulate their CSE and ferritin expression, limiting oxidative stress and maintaining vascular health. In contrast, CSE‐deficient (CSE−/−) mice fail to induce ferritin, leading to elevated oxidative stress, vascular remodeling, and hypertension.
Arif HM, Fu M, Verma R, Wang R.
europepmc +2 more sources
The roles of the novel RNA-binding protein ANKHD1 in shear stress-mediated endothelial dependent-vasoprotection [PDF]
, 2022 Rationale and Hypothesis: Cardiovascular disease is the top cause of death worldwide. Atherosclerosis is a chronic cardiovascular disease, caused by the accumulation of lipids in large and medium arteries.
Alahmadi, Areej
core +5 more sources
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging. [PDF]
Aging CellAging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Milan M +13 more
europepmc +2 more sources
Journal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023 Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang +11 more
wiley +1 more source
Targeting Heme Oxygenase-1 in the Arterial Response to Injury and Disease
Antioxidants, 2020 Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into carbon monoxide (CO), iron, and biliverdin, which is rapidly metabolized to bilirubin. The activation of vascular smooth muscle cells (SMCs) plays a critical role in mediating the aberrant ...
William Durante
doaj +1 more source
Global Challenges, Volume 7, Issue 5, May 2023., 2023 Microalgae biomass has tremendous potential as a sustainable source of alternative proteins. Enzymatic processing of microalgae proteins yields structurally diverse peptides with multiple biofunctional properties. This review discusses recent developments in microalgae protein‐derived bioactive peptides relevant in cardiovascular disease management ...
Chukwunonso E. C. C. Ejike +3 more
wiley +1 more source
ACE INHIBITOR POSSIBILITIES IN CLINICAL PRACTICE: WHAT WE KNOW ABOUT THEM?
Рациональная фармакотерапия в кардиологии, 2016 New possibilities of ACE inhibitors application on the base of international trails review are presented. Traditional therapy areas of ACE inhibitors (hypertension, heart failure) are well known.
D. V. Nebieridze, A. S. Safarian
doaj +1 more source
Paracrine effects of bone marrow-derived endothelial progenitor cells: cyclooxygenase-2/prostacyclin pathway in pulmonary arterial hypertension. [PDF]
PLoS ONE, 2013 BACKGROUND: Endothelial dysfunction is the pathophysiological characteristic of pulmonary arterial hypertension (PAH). Some paracrine factors secreted by bone marrow-derived endothelial progenitor cells (BMEPCs) have the potential to strengthen ...
Dong-Mei Jiang +4 more
doaj +1 more source
Treatment of Patients Chronic Coronary Heart Disease and Type 2 Diabetes Mellitus
Архивъ внутренней медицины, 2023 The combination of chronic coronary heart disease and type 2 diabetes mellitus in a patient has high medical importance, because relevance of the problem increases every year. Modern requirements for the provision of high-quality medical care to patients
E. V. Shсhukina +6 more
doaj +1 more source