Results 11 to 20 of about 59,545 (218)
Patterns of genome-wide VDR locations.
PLoS ONE, 2014 The genome-wide analysis of the binding sites of the transcription factor vitamin D receptor (VDR) is essential for a global appreciation the physiological impact of the nuclear hormone 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3).
Pauli Tuoresmäki +4 more
doaj +3 more sources
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]
, 2016 1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D +4 more
core +5 more sources
Evaluation of VDR and PAI allelic genes in patients with avascular necrosis of the femoral head
Гений oртопедии, 2021 Objective To evaluate the informative value of the carrier status for allelic variations that determine the sensitivity of tissues to calcitriol (VDR) and are involved in familial thrombophilia and hypofibrinolysis (PAI-1) as molecular genetic markers ...
Evgenii E. Volkov +3 more
doaj +1 more source
Vitamin D and extraskeletal effects [PDF]
Romanian Journal of Medical Practice, 2017 Vitamin D is a fat soluble vitamin and a steroid hormone with endocrine, paracrine and autocrine actions. The two major forms are vitamin D2 (ergocalcifeol) and vitamin D3 (cholecalciferol), the active hormone being calcitriol.
Andra BURUIANĂ +6 more
doaj +1 more source
The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity
EXCLI Journal : Experimental and Clinical Sciences, 2022 Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity.
Zorana Dobrijević +6 more
doaj +1 more source
Vitamin D Receptor (VDR) Regulation of Voltage-Gated Chloride Channels by Ligands Preferring a VDR-Alternative Pocket (VDR-AP) [PDF]
Molecular Endocrinology, 2011 We have postulated that the vitamin D receptor (VDR) contains two overlapping ligand binding sites, a genomic pocket and an alternative pocket (AP), that mediate regulation of gene transcription and rapid responses, respectively. Flexible VDR + ligand docking calculations predict that the major blood metabolite, 25(OH)-vitamin D3 (25D3), and curcumin ...
Danusa, Menegaz +5 more
openaire +2 more sources
Proceedings of the 2nd ACM Conference on Information-Centric Networking, 2015 In this work, we propose VDR, a routing scheme based on virtual domains -- domains that are not bound to physical routers -- to exploit the benefits of aggregation and hashing while overcoming their disadvantages. VDR addresses the FIB scalability issue in CCN by facilitating aggregation without compromising on the advantages of CCN such as ease of ...
Li, Jie +4 more
openaire +3 more sources
Protective Role of Vitamin D in Renal Tubulopathies
Metabolites, 2020 Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3.
Guido Gembillo +5 more
doaj +1 more source
Гений oртопедии, 2023 Introduction Bone metabolic markers informatively reflect the complex balance of bone formation/resorption and are widely used in clinical practice. Genetic predisposition also plays a significant role in the etiopathogenesis of aseptic necrosis of the ...
Evgeny E. Volkov +3 more
doaj +1 more source
Journal of Pure and Applied Microbiology, 2021 This study was carried out to investigate the relationship between common variants in two vitamin D pathway genes (VDR and CYP27B1) and vitamin D3 serum levels.
Hormoz Selahvarzi +5 more
doaj +1 more source