Results 21 to 30 of about 25,428 (209)
Diabetes, Metabolic Syndrome and Obesity, 2022 Wenjie Wen,1,2,* Bin Huang,1,2,* Shandong Ye1,2 1Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of University of Science and Technology of China (USTC), Department of Life Sciences and Medicine, University ...
Wen W, Huang B, Ye S
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Vitamin D and extraskeletal effects [PDF]
Romanian Journal of Medical Practice, 2017 Vitamin D is a fat soluble vitamin and a steroid hormone with endocrine, paracrine and autocrine actions. The two major forms are vitamin D2 (ergocalcifeol) and vitamin D3 (cholecalciferol), the active hormone being calcitriol.
Andra BURUIANĂ +6 more
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Bile acid dysmetabolism in inflammatory bowel diseases
Alʹmanah Kliničeskoj Mediciny, 2023 Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in ...
Daria A. Kuznetsova +2 more
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Гений oртопедии, 2023 Introduction Bone metabolic markers informatively reflect the complex balance of bone formation/resorption and are widely used in clinical practice. Genetic predisposition also plays a significant role in the etiopathogenesis of aseptic necrosis of the ...
Evgeny E. Volkov +3 more
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Protective Role of Vitamin D in Renal Tubulopathies
Metabolites, 2020 Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3.
Guido Gembillo +5 more
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2023 Introduction. Vitamin D deficiency may be a natural predictor of the onset of coronary heart disease (CHD) and myocardial infarction (MI) at a young age. The results of studies of the various variants association of the vitamin D receptor (VDR) gene with
O. A. Bercovich +8 more
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The impact of VDR expression and regulation in vivo [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2018 The vitamin D receptor (VDR) mediates the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). These actions include orchestration of mineral homeostasis which is coordinated by the kidney, intestine, bone and parathyroid gland wherein the VDR transcriptionally regulates expression of the genes involved in this complex process ...
Seong Min, Lee +4 more
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Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer
Nucleic Acids Research, 1994 Nuclear receptors for the thyroid hormone and vitamin A and D cooperate with the retinoid X receptor (RXR) in activating the transcription. Although the hormone response elements for these receptors have been proposed in which spacing of the direct repeated motifs determine the specificity (so called 3-4-5 rule), vitamin D response elements (VDREs) in ...
J, Nishikawa +4 more
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Very important pharmacogene summary for VDR [PDF]
Pharmacogenetics and Genomics, 2012 The vitamin D receptor (VDR) binds the active form of vitamin D (1,25-dihydroxyvitamin D3). It belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. The gene was cloned by Baker and colleagues in 1988 and maps to chromosome 12q13.11 [1].
Poon, Audrey H. +9 more
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Association of rs2476601 and rs1544410 with Onset of T1D in Youngsters of Lahore, Pakistan
Journal of Bioresource Management, 2016 The PTPN22 gene plays vital role in T1D onset by encoding Lymphoid-specific phosphatase (LYP) that lead to T-cell receptor-associated CsK kinase inactivation and preventing T-cell spontaneous activation by dephosphorylation.
Andleeb Batool +3 more
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